TY - JOUR T1 - Ototoxicity of cypermethrin in Wistar rats JO - Brazilian Journal of Otorhinolaryngology (English Edition) T2 - AU - Cunha,Eduarda Oliveira AU - Reis,Aléxia dos AU - Macedo,Mateus Belmonte AU - Machado,Márcia Salgado AU - Dallegrave,Eliane SN - 18088694 M3 - 10.1016/j.bjorl.2019.02.007 DO - 10.1016/j.bjorl.2019.02.007 UR - http://www.bjorl.org/en-ototoxicity-cypermethrin-in-wistar-rats-articulo-S1808869418306992 AB - IntroductionThis study presents the effect of cypermethrin on the cochlear function in Wistar rats post-subchronic inhalation exposure. Worldwide several pesticides are described as causing health disorders. Cypermethrin is currently one of the most commonly used, however, little is known about its harmful effects, especially related to hearing. Human studies have associated pesticides with hearing disorders, but they present limited conclusions due to the multiple factors to which the population is exposed, such as noise. ObjectiveMimic human exposure to cypermethrin and to verify the effects on cochlear function. MethodsIt is a subchronic inhalation animal study (6 weeks, 4hours/day), using 36 male Wistar aged 60 day. Rats were randomly assigned into three groups: Control (12 rats exposed to inhalation of water); Positive Control for auditory lesion (12 rats administrated with 24mg/kg intraperitoneal cisplatin); Experimental (12 rats exposed to inhalation of cypermethrin – 0.25mg/L). Animals were evaluated by distortion product otoacoustic emissions pre- and post-exposure. ResultsThe frequencies of 8, 10 and 12kHz in both ears (right p=0.003; 0.004; 0.008 and left 0.003; 0.016; 0.005 respectively) and at frequencies 4 and 6 in the right ear (p=0.007 and 0.015, respectively) in the animals exposed to cypermethrin resulted in reduction. ConclusionSubchronic inhalation exposure to cypermethrin provided ototoxicity in rats. ER -