Preferential glutamine uptake by cochlear hair cells: implications for the afferent cochlear transmitter
ReferenceS (25)
- et al.
Aspartate aminotransferase immunoreactivity in the cochlea of the guinea pig
Hearing Res.
(1982) - et al.
Lack of effect ofdl-α-aminoadipate, and excitatory amino acid antagonist, on cat auditory nerve responses to sound
Neuropharmacology
(1980) - et al.
Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate
Brain Research
(1979) Glutamine uptake by isolated rat brain mitochondria
Neuroscience
(1982)- et al.
Fine structural localization of glutamine synthetase in astrocytes of rat brain
Brain Research
(1979) Comparative study of the release of glutamate and GABA, newly synthesized from glutamine, in various regions of the central nervous system
Neurosci. Lett.
(1980)- et al.
Present status and significance of the glutamine cycle in neural tissues
Life Sci.
(1981) Activity-related increases of glucose utilization associated with reduced incorporation of glucose into its derivatives
Brain Res.
(1976)- et al.
Formation of γ-glutamyl-taurine in the rat brain
Neurosci. Lett.
(1981) Glutamate and aspartate mimic the afferent transmitter in the cochlea
Exp. Brain Res.
(1979)
Effects of putative transmitter on afferent cochlear transmission
Ann. Otol. Rhinol. Laryng.
Action of putative neurotransmitters in the guinea pig cochlea
Exp. Brain Res.
Cited by (40)
Cochlear homeostasis: a molecular physiological perspective on maintenance of sound transduction and auditory neurotransmission with noise and ageing
2020, Current Opinion in PhysiologyCitation Excerpt :In mice, GLAST promoter – driven Discosoma red (DsRed) reporter fluorescence was confined to these glia-like cells and not the IHC or SGN, and utilising patch-clamp, d-aspartate-induced currents were pronounced in IPC but absent from IHC, and in IPC from GLAST knockout mice [84]. Recycling of glutamate therefore occurs via conversion to glutamine [85] via glutamine synthetase in these supporting cells, with transfer to the apical region of the IHC via SAT1 (system A transporter 1 (SLC38A1)), for reconversion via glutaminase [86] (Figure 2). The physiological significance of metabotropic glutamate receptors (mGluR) in cochlear neurotransmission is weakly understood compared with ionotropic glutamatergic transmission.
Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status
2020, Brazilian Journal of OtorhinolaryngologyCitation Excerpt :Only a few studies have investigated glutamine cochlear metabolism. Ryan and Schwartz41 traced glutamine uptake into cochlear hair cells, and observed higher levels in the inner hair cells than those of the outer cells. This suggests the existence of a membrane high-affinity system for glutamine transport in cochlea.
Chemical synaptic transmission in the cochlea
1995, Progress in Neurobiology
Supported by NIH/NINDS Grants NS14945, NS00176, NS09823 and NS14503, and by the Research Service of the Veterans Administration.