ReviewPlasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications☆☆
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Graphical abstract
Abbreviations
AA
arachidonic acid
APAP
acetaminophen
aSMase
acid sphingomyelinase
ATP
adenosine triphosphate
BA
benzyl alcohol
BM
bimoclomol
CaMKII
calmodulin kinase II
Cdase
ceramidase
CHO
Chinese hamster ovary
CHOL
cholesterol
CRA
crotonaldehyde
DAG
diacylglycerol
DMPC
1,2-dimyristoyl-sn-glycero-3-phosphocholine
DPH
1,6-diphenyl-1,3,5-hexatriene
EGFR
epidermal growth factor receptor
ERK1/2
extracellular-signal-regulated kinase
FRET
fluorescence resonance energy transfer
GCS
glucosylceramide synthase
GFP
green fluorescent protein
GFR
growth factor receptor
GlcCer
glucosylceramide
GPI
glycophosphatidylinositol
GR
glucocorticoid receptor
GSK3
glycogen synthase kinase-3
HNE
4-hydroxynonenal
HSF1
heat shock factor 1
HSP
heat shock protein
HSR
heat shock response
IP3
inositol trisphosphate
LB
luria broth
Ld
liquid disordered
Lo
liquid ordered
LPA
lysophosphatidic acid
LPA
alpha lipoic acid
LPC
lysophosphatidylcholine
LPS
lysophosphatidylserine
MALDI
matrix-assisted laser desorption/ionization
MAPK
mitogen-activated protein kinase
MBCD
methyl-β-cyclodextrin
MD
molecular dynamics
MPS
membrane physical state
mTOR
target of rapamycin
NADA
N-arachidonoyl-dopamine
NPN
1-N-phenylnaphthylamine
PhA
phenethyl alcohol
PHB
poly-(R)-3-hydroxybutyrate
PI3K
phosphatidylinositol-3-kinase
PI4P
phosphatidylinositol 4-phosphate
PIP2
phosphatidylinositol 4,5-bisphosphate
PIP3
phosphatidylinositol-3,4,5-triphosphate
PKA
protein kinase A
PKC
protein kinase C
PLA2
phospholipase A2
PLC
phospholipase C
PLD
phospholipase D
POPC
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
POPE
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
S1P
sphingosine-1-phosphate
SFA
saturated fatty acids
SGT
glucosyltransferase
SK1
sphingosine kinase 1
SM
sphingomyelin
SPC
sphingosylphosphorylcholine
TIRF
total internal reflection fluorescence
TOCCSL
Thinning Out Clusters while Conserving the Stoichiometry of Labeling
TRP
transient receptor potential channel
UFA
unsaturated fatty acids
YFP
yellow fluorescent protein
Keywords
Lipid raft
TRP channel
Heat shock response
Stress hormone
Cell-to-cell heterogeneity
Lipidomics
Membrane lipid therapy
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This article is part of a Special Issue entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy.
Copyright © 2013 The Authors. Published by Elsevier B.V.