Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Oral and Maxillofacial SurgeryCan platelet-rich fibrin improve healing after surgical treatment of medication-related osteonecrosis of the jaw? A pilot study
Section snippets
Study sample
According to the Declaration of Helsinki on medical protocol and ethics, the regional Ethical Review Board of Central Calabria (reference for Magna Graecia University of Catanzaro, Catanzaro, Italy) approved the study. The study was designed as a prospective randomized, single-blind, monocentric clinical trial. The sample size was not calculated. Informed consent was obtained from all patients enrolled. Forty-seven patients who were diagnosed with MRONJ during the period November 2015 to
Patient characteristics
The study included 47 patients (24 women and 23 men). They were divided into 2 groups: (1) 24 patients (10 women and 14 men) treated with PRF in addition to traditional surgical removal of necrotic bone (PRF group); (2) 23 patients (14 women and 9 men) treated by following the traditional treatment protocol (non-PRF group). Detailed patient data are shown in Table I. The mean age of the patients was 74.7 ± 6.5 years (75.5 ± 5.6 years in the PRF group and 73.9 ± 7.4 years in the non-PRF group).
Discussion
The goal of treatment for patients developing MRONJ is to preserve quality of life, especially in those patients who have active disease. In particular, it is important to control pain, manage infection, and promote healing of surrounding bone. Although conservative treatment may resolve the patient's complaint, in cases where prolonged bone exposure shows no improvement, additional treatment is needed. Typically, these patients have stage II or III (AAOMS classification) disease, where the
Conclusions
Long-term evaluation showed no statistical differences between the PRF and non-PRF groups in terms of mucosal healing and absence of infection. Local application of PRF after bone surgery showed significant improvement in terms of quality of life in short-term follow-up and resulted in reduction in re-interventions necessary for healing.
Considering the limitations of the present study (a small study sample, monocentric study, and heterogeneous drug administrations), our results are not
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