Growth factors and wound healing: Part II. Role in normal and chronic wound healing1

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Wound healing is a complex biologic process that involves the integration of inflammation, mitosis, angiogenesis, synthesis, and remodeling of the extracellular matrix. Part II of this two-part series reviews the results of experiments that indicate that growth factors and their receptors regulate key aspects of soft and hard tissue repair. Results of clinical studies are also reviewed that demonstrate that growth factor treatment accelerates healing of normal tissues and promotes healing of impaired wounds.

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    1

    This work was supported in part by the U.S. Army Medical Research and Development Command under Contract No. DAMD17-91-C-1095 and by Grant EY 05587 from the National Institutes of Health.

    1

    From the Departments of Surgery, University of Florida, Gainesville, Florida

    2

    Departments of Obstetrics and Gynecology, University of Florida, Gainesville, Florida

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