Elsevier

Blood Reviews

Volume 7, Issue 2, June 1993, Pages 104-113
Blood Reviews

Platelet volume: Laboratory measurement and clinical application

https://doi.org/10.1016/S0268-960X(05)80020-7Get rights and content

Summary

Modern cell analyzers routinely produce platelet indices, but many clinicians do not utilize them in clinical decision-making. In part this can be attributed to difficulties with their laboratory measurement. The mean platelet volume is dependent on a number of variables, including time of analysis after venepuncture, method of analysis, anticoagulant used and specimen storage temperature. The influence of these laboratory variables is significant and reproducible mean platelet volumes are dependent on standardized laboratory methodology. When pre-analysis factors are controlled, alterations in platelet volume can be demonstrated in a number of disease states and assessment of platelet volume can be useful in the monitoring and diagnosis of patients. An understanding of the pathophysiology of alterations in platelet volume and of the inverse relationship between platelet volume and count is a prerequisite for the successful clinical application of platelet volume measurements.

References (88)

  • MartinJF et al.

    Influence of platelet size on outcome after myocardial infarction

    Lancet

    (1991)
  • CastaldiP et al.

    The bleeding disorder of uremia

    Lancet

    (1966)
  • BerridgeMV et al.

    Effect of human erythropoietin on megakaryocyte and on platelet production in the rat

    Blood

    (1988)
  • ZauliG et al.

    Impaired In vitro growth of purified haematopoietic progenitors in HIV-1 seropositive thrombocytopenic individuals

    Blood

    (1992)
  • BessmanJD et al.

    Use of mean platelet volume improves detection of platelet disorders

    Blood Cells

    (1985)
  • GilesC

    The platelet count and mean platelet volume

    Br J Haematol

    (1981)
  • BessmanJD et al.

    Platelet size in health and hematologic disease

    Am J Clin Pathol

    (1982)
  • McShineRL et al.

    Differences between the effects of EDTA and citrate anticoagulants on platelet count and mean platelet volume

    Clin Lab Haematol

    (1990)
  • LevinJ et al.

    The Inverse relation between platelet volume and platelet number

    J Lab Clin Med

    (1983)
  • ThompsonCB et al.

    The role of anticoagulation in the measurement of platelet volumes

    Am J Clin Pathol

    (1983)
  • ThreatteGA et al.

    Mean platelet volume: The need for a reference method

    Am J Clin Pathol

    (1984)
  • TrowbridgeEA et al.

    The routine measurement of platelet volume: a comparison of light-scattering and aperture impedance technologies

    Clin Phys Physiol Meas

    (1985)
  • LippiU et al.

    Quality control of mean platelet volume: a chimera

    Am J Clin Pathol

    (1983)
  • BainBJ

    Platelet count and platelet size in males and females

    Scand J Haematol

    (1985)
  • O'BrienJR

    A relationship between platelet volume and platelet number

    Thromb Diath Haemorrh

    (1974)
  • LamparelliRD et al.

    Platelet parameters: platelet counts and mean platelet volume in normal and pregnant subjects

    South Afr Med J

    (1988)
  • PenningtonDG et al.

    Platelet density and size: The interpretation of heterogeneity

    Br J Haematol

    (1976)
  • MartinJF et al.

    Acute and chronic changes in platelet volume after cardiopulmonary bypass induced thrombocytopenia in man

    Thromb Haemost

    (1987)
  • ThompsonCB et al.

    Platelet size as a determinant of platelet function

    J Lab Clin Med

    (1983)
  • BessmanJD

    The relation of megakaryocyte ploidy to platelet volume

    Am J Hematol

    (1984)
  • CorashL et al.

    Regulation of thrombopoiesis: Effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume

    Blood

    (1987)
  • CorashL et al.

    Regulation of platelet heterogeneity: Effects of thrombocytopenia on platelet volume and density

    Exper Hematol

    (1990)
  • PeningtonDG et al.

    Megakaryocytes in states of altered platelet production: Cell numbers, size and DNA content

    Br J Haematol

    (1970)
  • StenbergPE et al.

    Ultrastructural analysis of acute immune thrombocytopenia in mice: dissociation between alterations in megakaryocytes and platelets

    J Cell Physiol

    (1989)
  • ChamberlainKG et al.

    Properties of the exchangeable splenic platelets released into the circulation during exercise-induced thrombocytosis

    Am J Hematol

    (1990)
  • FreedmanM et al.

    Heterogeneity of rabbit platelets: Preferential splenic sequestration of megathrombocytes

    Br J Haematol

    (1975)
  • PeatfieldRC et al.

    The effects of exercise on platelet numbers and size

    Med Lab Sci

    (1985)
  • LandeK et al.

    Effects of adrenaline infusion on platelet number, volume and release reaction

    Thromb Haemost

    (1985)
  • O'GradyJG et al.

    Influence of splenectomy and the functional hyposplenism of coeliac disease on platelet count and volume

    Scand J Haemat

    (1985)
  • LombartsAJP et al.

    Basic principles and problems of haemacytometry

    Ann Clin Biochem

    (1986)
  • RowanRM

    Blood cell volume analysis

    (1983)
  • LippiU et al.

    Unpredictable effects of K3EDTA on mean platelet volume

    Am J Clin Pathol

    (1987)
  • D'ErasmoE et al.

    Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction

    J Intern Med

    (1990)
  • RosevearSK et al.

    Platelet dimensions in pregnancy induced hypertension

    New Zealand Med J

    (1986)
  • Cited by (220)

    View all citing articles on Scopus
    1

    S. R. Jackson, J. M. Carter, Haematology Department, Wellington Hospital and School of Medicine, Riddiford Street, Newtown, Wellington, New Zealand.

    View full text