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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="par0025" class="elsevierStylePara elsevierViewall">Obstructive sleep apnea &#40;OSA&#41; is a respiratory disorder characterized by recurrent airway obstruction during sleep&#44; and its causes are multifactorial&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The population prevalence is high&#44; and cardiovascular alterations are among its consequences&#46; Treatment is sometimes multidisciplinary&#44; with the continuous positive airway pressure &#40;CPAP&#41; device being the gold standard&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> To understand the pathology&#44; we need to understand that the causes are varied and&#44; therefore&#44; the treatment must be individualized&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Among the anatomical findings of OSA&#44; one can cite septal deviation&#44; palatine tonsil hypertrophy&#44; transverse maxillary atresia&#44; maxillomandibular retrusion&#44; or even a combination of them&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Other phenotypes were defined as&#58; &#40;1&#41; anatomically compromised upper airways &#40;UAs&#41; &#40;pharyngeal critical closing pressure &#40;Pcrit&#41; &#40;2&#41; Inappropriate responsiveness of the UA dilator muscles during sleep&#44; &#40;3&#41; low arousal threshold &#40;4&#41; unstable ventilatory control &#40;high loop gain&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Ankyloglossia is considered a congenital anomaly found in 4&#37;&#8211;5&#37; of the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> It can be inherited as an X-linked autosomal dominant trait&#44; being more common in males&#46; The presence of a shortened lingual frenulum has been reported in genetically-related syndromes such as Beckwith-Wiedemann&#44; digital-orofacial syndrome&#44; cleft palate and Opitz syndrome&#44; but all mutations associated with these syndromes are not known&#46; It is possible that the shortened lingual frenulum is associated with tongue malposition due to an unknown mutation&#44; but there is no evidence to support this hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">A shortened lingual frenulum has been shown to lead to mouth breathing and abnormal development of the oral cavity&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> increasing the risk of upper airway &#40;UA&#41; collapsibility during sleep&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The interaction between bone growth stimulation and the absence of nasal breathing can lead to an abnormal orofacial development and reduction in the ideal size of the UAs&#44; causing abnormal breathing during sleep over time&#44; initially with flow limitation and then with progressive worsening of obstructive events&#44; leading to Obstructive Sleep Apnea&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Therefore&#44; there is evidence of an association between the presence of a shortened lingual frenulum and changes in craniofacial growth&#44; with possible consequences on the caliber of the upper airways&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Ankyloglossia limits the mobility of the tongue&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> impairing the sucking&#44; chewing&#44; deglutition and speaking functions&#46; With the alteration of the stomatognathic functions&#44; the stability of the structure is not maintained&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">When changes in the lingual frenulum are not treated early&#44; they can compromise breastfeeding&#44; which plays an important role in the development of bone structures and maintenance of nasal breathing&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Several studies have reported that a shortened lingual frenulum can lead to changes in craniofacial growth&#44; with respiratory consequences&#44; including obstructive sleep apnea&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objective</span><p id="par0070" class="elsevierStylePara elsevierViewall">To investigate the evidence on the association between ankyloglossia and obstructive sleep apnea&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><p id="par0075" class="elsevierStylePara elsevierViewall">An integrative literature review was carried out in the following databases&#58; Pubmed&#44; Scopus&#44; Embase&#44; Web of Science&#44; Lilacs and ProQuest&#46; The PECOS criteria were employed to structure the search strategy &#40;P&#8239;&#61;&#8239;Participants&#59; E&#8239;&#61;&#8239;Exposure&#59; C&#8239;&#61;&#8239;Comparison&#59; O&#8239;&#61;&#8239;Outcomes&#44; S&#8239;&#61;&#8239;Types of Study&#41;&#44; shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The keywords and free terms used corresponded to the established PECOs &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Observational and interventional studies that assessed the lingual frenulum in children with sleep-disordered breathing were included&#46; As exclusion criteria&#44; studies in animals&#44; <span class="elsevierStyleItalic">in vitro</span>&#44; letters to the editor&#44; expert opinions&#44; and other reviews &#40;secondary studies&#41; were excluded&#46; There was no limitation related to language or year of publication&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The identified articles were exported to Endnote Web and&#44; subsequently&#44; to the Rayyan manager&#44; where the first phase was carried out&#44; with the reading of titles and abstracts&#46; The reading and selection steps were performed by two reviewers&#44; blindly&#46; In case of conflicts&#44; a third reviewer was called in&#46; The articles included in the first phase were read in full for the final selection&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The selected articles were analyzed regarding the study design&#44; sample&#44; characterization of the lingual frenulum and sleep assessment&#44; as well as the main results and conclusions&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The protocol registered in Prospero under number CRD42020206899&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 97 articles were identified&#46; After evaluating the duplicates&#44; 16 articles were excluded&#46; Thus&#44; the reviewers read 71 titles and abstracts in the first phase&#46; Of these&#44; 10 were included by both and 6 showed conflicts&#46; After the evaluation by the third reviewer&#44; 15 articles were included for full reading&#46; Of the 15 articles&#44; 11 were excluded by the authors for not meeting the inclusion criteria or for having a study design that met the exclusion criteria&#46; In the end&#44; four articles were included in the study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The article by Guilleminault et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> assessed 150 children aged 3&#8211;12 years in a retrospective study comparing children with a shortened lingual frenulum and children with a normal one&#46; To measure the lingual frenulum&#44; a measurement was taken during the maximum opening of the lower left incisor to the upper left incisor&#44; and then a measurement was taken with the mouth wide open with the tip of the tongue touching the incisor papilla&#46; This measure was considered normal if the difference between the two was &#60;50&#37;&#46; There was a statistical significance between the Apnea&#47;Hypopnea Index &#40;AHI&#41; of 13&#46;06&#8239;&#177;&#8239;4&#46;17 in the shortened lingual frenulum group <span class="elsevierStyleItalic">versus</span> 11&#46;36&#8239;&#177;&#8239;5&#46;39 in the normal lingual frenulum group &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;025&#41;&#46; The shortened lingual frenulum was predictive of a higher AHI in male &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;0069&#41;&#44; but not in female individuals &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;8615&#41;&#46; The study concluded that an untreated shortened lingual frenulum at birth is associated with OSAS at older age&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In another retrospective study&#44; Villa et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> assessed 504 children aged 6&#8211;14 years and evaluated subjective and objective criteria for OSAS&#44; using Kotlow&#8217;s criteria <a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> for measuring the lingual frenulum&#44; measuring the free length of the tongue &#40;the distance between the insertion of the lingual frenulum at the base of the tongue and the tip of the tongue&#41;&#44; considering the lingual frenulum to be shortened if the length were less than 16&#8239;mm&#46; In that study&#44; they concluded that of the 42 children at high risk for OSAS in a subjective assessment&#44; 18 &#40;42&#46;8&#37;&#41; had a shortened lingual frenulum&#44; and the incidence in the study was 114 patients &#40;22&#46;6&#37;&#41;&#46; In a multivariate logistic regression model&#44; the risk for OSAS in children with a shortened lingual frenulum was significantly higher than other possible factors&#44; such as obesity&#44; age&#44; gender&#44; and lingual tonus&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In the only prospective study included in this review&#44; Baxter et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> followed 37 children from 13 months to 12 years of age&#46; For the evaluation of the lingual frenulum&#44; Kotlow&#8217;s protocol was followed&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Twenty-four of them were snorers before being submitted to the lingual frenectomy&#44; of which 16 improved the snoring after the surgery&#46; The study concluded that&#44; in addition to improved sleep&#44; there was an improvement in speech and deglutition of solid foods&#44; as reported by parents&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In a retrospective cohort&#44; Zaghi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> followed individuals of all ages&#44; including 110 children&#46; The lingual frenulum was assessed using the lingual frenulum and tongue mobility scale&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> which includes a comparison of the measurements of maximum mouth opening and opening with the tip of the tongue on the palatine papilla&#44; considering a normal measurement when there is less than 50&#37; of difference between them&#46; The study concluded that lingual frenuloplasty with myofunctional therapy is safe and potentially effective for the treatment of mouth breathing&#44; snoring and myofascial tension&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">There is agreement between the four analyzed studies that the lingual frenulum alteration interferes with the growth of anatomical structures&#44; leading to alterations in respiratory&#44; suction&#44; chewing and speech functions&#46; Marchesan<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> reports that among the alterations caused by an altered lingual frenulum&#44; the most common are those related to speech&#44; nutrition&#44; with special attention to breastfeeding&#44; and deglutition functions&#46; There is a consensus in the literature that stomatognathic functions are affected by alterations in the lingual frenulum&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Considering the results found in the retrospective study by Guilleminault et al&#46;&#44; in which two groups were studied&#44; one with a shortened lingual frenulum and the other with a normal one&#44; where significant anatomical differences were observed between the two groups&#44; and the group with the shortened lingual frenulum had a high palate and maxillary atresia&#44; favoring airway collapsibility&#44; a question arises&#58; would early treatment have an effect&#44; improving the symptoms and potentially preventing the onset of a more severe picture of obstructive disorder&#63;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Zaghi et al&#46; published a retrospective cohort study aimed at exploring the safety and efficacy of lingual frenuloplasty and myofunctional therapy in patients with restricted tongue mobility&#46; A total of 348 patients who complained of one or more of the following symptoms were included&#58; mouth breathing &#40;n&#8239;&#61;&#8239;226&#41;&#44; snoring &#40;n&#8239;&#61;&#8239;151&#41;&#44; dysfunctional deglutition pattern &#40;n&#8239;&#61;&#8239;130&#41;&#44; myofascial tightness &#40;n&#8239;&#61;&#8239;44&#41; and&#47;or pain or tension &#40;n&#8239;&#61;&#8239;151&#41; and who were treated with lingual frenuloplasty and myofunctional therapy&#46; Anterior lingual frenectomy was performed in 41 of the patients &#40;11&#46;7&#37;&#41;&#44; with complementation elsewhere when persistent restrictions in tongue mobility were identified&#46; A myofunctional therapy protocol was performed one month preoperatively and two months after lingual frenectomy&#46; Pain severity and complications were rated on a 10-point visual analogue scale&#46; Changes in overall health-related quality of life and overall satisfaction were assessed using the Likert Scale&#46; Snoring complaints and sleep quality were also assessed with the abovementioned scales&#44; with no nocturnal monitoring exam being performed&#46; The results obtained were an 87&#37; improvement in quality of life through improved mouth breathing &#40;78&#46;4&#37;&#41;&#44; snoring &#40;72&#46;9&#37;&#41;&#44; teeth clenching &#40;91&#46;0&#37;&#41; and&#47;or myofascial tension &#40;77&#46;5&#37;&#41;&#46; The authors affirm that lingual frenuloplasty associated with myofunctional therapy is safe and potentially effective for the treatment of mouth breathing&#44; snoring and myofascial tension&#44; and further studies are required to identify the ideal candidates for this treatment&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Baxter et al&#46; in 2020 published a prospective study of lingual frenectomy carried out with LightScalpel CO<span class="elsevierStyleInf">2</span> laser&#44; followed by myofunctional therapy carried out in 37 patients &#40;mean age 4&#46;2 years&#44; ranging from 13 months to 12 years&#41;&#44; of which 62&#37; were boys and 38&#37; girls&#46; The degree of lingual mobility restriction was assessed using Kotlow&#8217;s classification scale&#46; The study comprised the assessment of speech&#44; eating&#44; sleep&#44; and other related symptoms reported on a yes&#47;no basis&#46; The results observed in the first week were that 76&#37; of the parents reported an improvement in speech&#44; 69&#37; observed an improvement in feeding and 85&#37; observed that their children&#39;s sleep improved&#46; Within one month&#44; 89&#37; of parents reported improved speech&#44; 83&#37; observed improved feeding&#44; and 83&#37; witnessed improved sleep&#46; According to the reports&#44; the children slept less frequently in awkward positions &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; kicked and moved less at night &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#46; They slept more soundly &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; woke up less tired &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; had less teeth grinding &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; less mouth breathing &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; and less snoring &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#46; Interestingly&#44; additional changes were observed by parents&#44; as children reported less neck pain &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;031&#41;&#44; less headaches &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;008&#41;&#44; less vomiting reflex &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; less mouth breathing &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; less reflux &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; less hyperactivity and inattention &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; and less constipation &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;004&#41;&#46; The authors stated that these results should encourage health professionals who treat children with speech&#44; eating and sleep disorders to assess possible tongue mobility restrictions in these patients&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In 2020&#44; Villa et al&#46; carried out a study with the aim of evaluating the presence of a shortened lingual frenulum as a risk factor for the development of sleep-disordered breathing &#40;SDB&#41; in school-age children&#44; whether or not they were snorers&#46; A total of 504 children were included&#44; aged between 6 and 14 years&#44; who were evaluated using a clinical tool used in the detection of children at high risk for SDB&#44; called sleep clinical record &#40;SCR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> The total SCR score is calculated considering nasal&#44; oropharynx&#44; dental&#44; craniofacial and occlusion abnormalities&#46; A total SCR score greater than or equal to 6&#46;5 is considered to be positive and associated with a high risk of OSA&#44; defined as an obstructive apnea&#47;hypopnea index &#40;AHI&#41; &#62;1 episode&#47;h&#46; Of the 504 children evaluated in this study&#44; 42 &#40;8&#46;3&#37;&#41; were at high risk for OSA&#44; as indicated by an SCR score &#62;6&#46;5&#46; Of these children&#44; 18 &#40;42&#46;8&#37;&#41; had a shortened lingual frenulum&#46; Among all 504 children&#44; a shortened lingual frenulum was found in 114 &#40;22&#46;6&#37;&#41;&#46; The multivariate logistic regression model showed that children with a shortened lingual frenulum had a significantly higher risk for a positive SCR and&#44; therefore&#44; a greater risk for developing OSA&#44; when compared to those with a normal lingual frenulum and that this higher risk was more significant even when other factors that can possibly affect the risk of OSA &#40;age&#44; gender&#44; tongue strength&#44; obesity&#41; were taken into account&#46; The authors concluded that an association between a shortened lingual frenulum and SDB was demonstrated&#44; and that a multidisciplinary approach is required to allow the early detection and timely treatment of craniofacial changes and potentially prevent SDB&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The studies by Zaghi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> and Baxter et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> showed that the association of myofunctional therapy with lingual frenectomy brought benefits to treated patients&#44; showing the importance of a multidisciplinary action&#46; In a study carried out in 2016 with 101 patients&#44; Ferr&#233;s-Amat et al&#46; submitted 96&#37; of patients to the myofunctional therapy&#44; starting one week before performing the lingual frenectomy&#44; aiming at increasing lingual mobility and reducing pain&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The four studies show significance in the relationship between the lingual frenulum alteration and OSA&#46; Further studies with surgical intervention are needed&#44; as well as polysomnographic examinations before and after lingual frenectomy in a larger sample of the population&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0160" class="elsevierStylePara elsevierViewall">The results of these studies suggest that speech&#44; mastication&#44; breathing and sleep can be affected by a tongue with restricted mobility&#44; and that its adequate surgical release associated with myofunctional therapy can result in functional and quality of life improvement&#46; The improvement in sleep quality was significant in patients included in the studies&#44; in which the intervention was performed&#44; because&#44; after the intervention&#44; the tongue was able to rest on the palate instead of resting on the floor of the mandible&#46; The possibility of tongue elevation&#44; and the releasing of the restriction so that the elevation normalizes&#44; is the reason for the observed improvement&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The studies included in the present review corroborate the association between ankyloglossia and obstructive sleep apnea&#46;</p><p id="par0161" class="elsevierStylePara elsevierViewall">This article is part of the master&#39;s thesis of the Surgery Sciences Program at the Faculty of Medical Sciences of the State University of Campinas &#40;UNICAMP&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Funding</span><p id="par0170" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of interest</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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      "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0005" class="elsevierStylePara elsevierViewall">An untreated shortened lingual frenulum at birth is associated with sleep apnea&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0010" class="elsevierStylePara elsevierViewall">A shortened lingual frenulum alters the craniofacial growth with respiratory consequences&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Lingual frenuloplasty associated with myofunctional therapy is effective in the treatment of snoring&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0020" class="elsevierStylePara elsevierViewall">In addition to improved sleep&#44; there was an improvement in the speech and deglutition functions&#46;</p></li></ul></p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To investigate the evidence on the association between ankyloglossia and obstructive sleep apnea&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">An integrative literature review was carried out in the databases&#46; Observational and interventional studies that assessed the lingual frenulum in children with sleep-disordered breathing were included&#46; As exclusion criteria&#58; studies in animals&#44; <span class="elsevierStyleItalic">in vitro</span>&#44; letters to the editor&#44; expert opinions&#44; other reviews&#46; The selected articles were analyzed regarding the study design&#44; sample&#44; characterization of the lingual frenulum and sleep assessment&#44; in addition to the main results and conclusions&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ninety-seven articles were identified&#44; but only 4 met the inclusion criteria&#46; Two retrospective studies concluded that the untreated shortened lingual frenulum at birth is associated with obstructive sleep apnea&#46; A prospective study concluded that there was an improvement in speech and deglutition after lingual frenectomy&#44; in addition to improved sleep&#46; A retrospective cohort concluded that lingual frenuloplasty combined with myofunctional therapy is effective in the treatment of snoring and mouth breathing&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The studies included in this review contribute to corroborate the association between ankyloglossia and obstructive sleep apnea&#46;</p></span>"
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            "titulo" => "Objectives"
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            "titulo" => "Methods"
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            "identificador" => "abst0020"
            "titulo" => "Results"
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            "identificador" => "abst0025"
            "titulo" => "Conclusion"
          ]
        ]
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    ]
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      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Peer Review under the responsibility of Associa&#231;&#227;o Brasileira de Otorrinolaringologia e Cirurgia C&#233;rvico-Facial&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0001">This article is part of the master&#39;s thesis of the Surgery Sciences Program at the Faculty of Medical Sciences of the State University of Campinas &#40;UNICAMP&#41;&#46;</p>"
      ]
    ]
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow diagram of the study selection&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PECOS</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">P</span></span><span class="elsevierStyleItalic">articipants</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">E</span></span><span class="elsevierStyleItalic">xposition</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obstructive sleep apnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">C</span></span><span class="elsevierStyleItalic">omparison</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No comparison&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">O</span></span><span class="elsevierStyleItalic">utcomes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies that performed the assessment of the lingual frenulum&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Types of</span><span class="elsevierStyleBold"><span class="elsevierStyleItalic">S</span></span><span class="elsevierStyleItalic">tudies</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Observational and interventional studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">PECOs criteria for the research strategy of the present study&#46;</p>"
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            "identificador" => "at0015"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Database&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Search&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Initial findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pubmed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; &#91;MeSH Terms&#93; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; &#91;MeSH Terms&#93; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; &#91;MeSH Terms&#93; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scopus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Embase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8216;sleep apnea&#44; obstructive&#8217;&#47;exp OR &#8216;sleep apnea&#44; obstructive&#8217; OR &#8216;apneas&#44; obstructive sleep&#8217; OR &#8216;obstructive sleep apneas&#8217; OR &#8216;sleep apneas&#44; obstructive&#8217; OR &#8216;obstructive sleep apnea syndrome&#8217;&#47;exp OR &#8216;obstructive sleep apnea syndrome&#8217; OR &#8216;obstructive sleep apnea&#8217;&#47;exp OR &#8216;obstructive sleep apnea&#8217; OR &#8216;osahs&#8217; OR &#8216;syndrome&#44; sleep apnea&#44; obstructive&#8217; OR &#8216;sleep apnea syndrome&#44; obstructive&#8217; OR &#8216;apnea&#44; obstructive sleep&#8217; OR &#8216;sleep apnea hypopnea syndrome&#8217;&#47;exp OR &#8216;sleep apnea hypopnea syndrome&#8217; OR &#8216;syndrome&#44; obstructive sleep apnea&#8217; OR &#8216;upper airway resistance sleep apnea syndrome&#8217; OR &#8216;syndrome&#44; upper airway resistance&#44; sleep apnea&#8217; OR &#8216;osa&#8217; OR &#8216;osas&#8217; OR &#8216;sleep apnea syndromes&#8217;&#47;exp OR &#8216;sleep apnea syndromes&#8217; OR &#8216;apnea syndrome&#44; sleep&#8217; OR &#8216;apnea syndromes&#44; sleep&#8217; OR &#8216;sleep apnea syndrome&#8217;&#47;exp OR &#8216;sleep apnea syndrome&#8217; OR &#8216;sleep hypopnea&#8217; OR &#8216;hypopnea&#44; sleep&#8217; OR &#8216;hypopneas&#44; sleep&#39; OR &#8216;sleep hypopneas&#8217; OR &#8216;apnea&#44; sleep&#8217;&#47;exp OR &#8216;apnea&#44; sleep&#8217; OR &#8216;apneas&#44; sleep&#8217; OR &#8216;sleep apnea&#8217;&#47;exp OR &#8216;sleep apnea&#8217; OR &#8216;sleep apneas&#8217; OR &#8216;sleep apnea&#44; mixed central and obstructive&#8217; OR &#8216;mixed central and obstructive sleep apnea&#8217; OR &#8216;sleep apnea&#44; mixed&#8217; OR &#8216;mixed sleep apnea&#8217; OR &#8216;mixed sleep apneas&#8217; OR &#8216;sleep apneas&#44; mixed&#8217; OR &#8216;hypersomnia with periodic respiration&#8217; OR &#8216;sleep-disordered breathing&#8217;&#47;exp OR &#8216;sleep-disordered breathing&#8217; OR &#8216;breathing&#44; sleep-disordered&#8217; OR &#8216;sleep disordered breathing&#8217;&#47;exp OR &#8216;sleep disordered breathing&#8217;&#41; AND &#40;&#8216;lingual frenum&#8217;&#47;exp OR &#8216;lingual frenum&#8217; OR &#8216;lingual frenulum&#8217;&#47;exp OR &#8216;lingual frenulum&#8217; OR &#8216;frenulum&#44; lingual&#8217;&#47;exp OR &#8216;frenulum&#44; lingual&#8217; OR &#8216;frenulums&#44; lingual&#8217; OR &#8216;lingual frenulums&#8217; OR &#8216;frenum&#44; lingual&#8217; OR &#8216;frenums&#44; lingual&#8217; OR &#8216;lingual frenums&#8217;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Web of Science&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lilacs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221; OR &#8220;Apneia Obstrutiva do Sono&#8221; OR &#8220;Apneia do Sono Obstrutiva&#8221; OR &#8220;Apneia do Sono Tipo Obstrutiva&#8221; OR &#8220;S&#237;ndrome da Apneia Obstrutiva do Sono&#8221; OR &#8220;S&#237;ndrome de Apneia do Sono por Resist&#234;ncia das Vias A&#233;reas Superiores&#8221; OR &#8220;Apnea Obstructiva del Sue&#241;o&#8221; OR &#8220;S&#237;ndromes da Apneia do Sono&#8221; OR &#8220;Apneia do Sono&#8221; OR &#8220;Hipersonia com Respira&#231;&#227;o Peri&#243;dica&#8221; OR &#8220;Respira&#231;&#227;o Desordenada Durante o Sono&#8221; OR &#8220;S&#237;ndromes de la Apnea del Sue&#241;o&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221; OR &#8220;Freio Lingual&#8221; OR &#8220;Frenillo Lingual&#8221; OR &#8220;Fr&#234;nulo da L&#237;ngua&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ProQuest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221; OR &#8220;Apneia Obstrutiva do Sono&#8221; OR &#8220;Apneia do Sono Obstrutiva&#8221; OR &#8220;Apneia do Sono Tipo Obstrutiva&#8221; OR &#8220;S&#237;ndrome da Apneia Obstrutiva do Sono&#8221; OR &#8220;S&#237;ndrome de Apneia do Sono por Resist&#234;ncia das Vias A&#233;reas Superiores&#8221; OR &#8220;Apnea Obstructiva del Sue&#241;o&#8221; OR &#8220;S&#237;ndromes da Apneia do Sono&#8221; OR &#8220;Apneia do Sono&#8221; OR &#8220;Hipersonia com Respira&#231;&#227;o Peri&#243;dica&#8221; OR &#8220;Respira&#231;&#227;o Desordenada Durante o Sono&#8221; OR &#8220;S&#237;ndromes de la Apnea del Sue&#241;o&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221; OR &#8220;Freio Lingual&#8221; OR &#8220;Frenillo Lingual&#8221; OR &#8220;Fr&#234;nulo da L&#237;ngua&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Search performed in the databases and the respective initial results&#46;</p>"
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      "titulo" => "References"
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Review article
Is ankyloglossia associated with obstructive sleep apnea?
Marieli Timpani Bussia,
Corresponding author
marielibussi@hotmail.com

Corresponding author.
, Camila de Castro Corrêab,c, Arthur Justi Cassettaria, Lorena Torres Giacomina, Ana Célia Fariaa, Ana Paula Sereni Manfredi Moreiraa, Itamá Magalhãesa, Mila Oliveira da Cunhaa, Silke Anna Theresa Weberd, Edilson Zancanellaa, Almiro José Machado Júniora
a Universidade Estadual de Campinas (UNICAMP), Departamento de Otorrinolaringologia Cabeça e Pescoço, Campinas, SP, Brazil
b Centro Universitário Planalto do Distrito Federal (UNIPLAN), Brasília, DF, Brazil
c Universidade de Brasília (UnB), Brasília, DF, Brazil
d Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina, Botucatu, SP, Brazil
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being more common in males&#46; The presence of a shortened lingual frenulum has been reported in genetically-related syndromes such as Beckwith-Wiedemann&#44; digital-orofacial syndrome&#44; cleft palate and Opitz syndrome&#44; but all mutations associated with these syndromes are not known&#46; It is possible that the shortened lingual frenulum is associated with tongue malposition due to an unknown mutation&#44; but there is no evidence to support this hypothesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">A shortened lingual frenulum has been shown to lead to mouth breathing and abnormal development of the oral cavity&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> increasing the risk of upper airway &#40;UA&#41; collapsibility during sleep&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The interaction between bone growth stimulation and the absence of nasal breathing can lead to an abnormal orofacial development and reduction in the ideal size of the UAs&#44; causing abnormal breathing during sleep over time&#44; initially with flow limitation and then with progressive worsening of obstructive events&#44; leading to Obstructive Sleep Apnea&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Therefore&#44; there is evidence of an association between the presence of a shortened lingual frenulum and changes in craniofacial growth&#44; with possible consequences on the caliber of the upper airways&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Ankyloglossia limits the mobility of the tongue&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> impairing the sucking&#44; chewing&#44; deglutition and speaking functions&#46; With the alteration of the stomatognathic functions&#44; the stability of the structure is not maintained&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">When changes in the lingual frenulum are not treated early&#44; they can compromise breastfeeding&#44; which plays an important role in the development of bone structures and maintenance of nasal breathing&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Several studies have reported that a shortened lingual frenulum can lead to changes in craniofacial growth&#44; with respiratory consequences&#44; including obstructive sleep apnea&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objective</span><p id="par0070" class="elsevierStylePara elsevierViewall">To investigate the evidence on the association between ankyloglossia and obstructive sleep apnea&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><p id="par0075" class="elsevierStylePara elsevierViewall">An integrative literature review was carried out in the following databases&#58; Pubmed&#44; Scopus&#44; Embase&#44; Web of Science&#44; Lilacs and ProQuest&#46; The PECOS criteria were employed to structure the search strategy &#40;P&#8239;&#61;&#8239;Participants&#59; E&#8239;&#61;&#8239;Exposure&#59; C&#8239;&#61;&#8239;Comparison&#59; O&#8239;&#61;&#8239;Outcomes&#44; S&#8239;&#61;&#8239;Types of Study&#41;&#44; shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The keywords and free terms used corresponded to the established PECOs &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Observational and interventional studies that assessed the lingual frenulum in children with sleep-disordered breathing were included&#46; As exclusion criteria&#44; studies in animals&#44; <span class="elsevierStyleItalic">in vitro</span>&#44; letters to the editor&#44; expert opinions&#44; and other reviews &#40;secondary studies&#41; were excluded&#46; There was no limitation related to language or year of publication&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The identified articles were exported to Endnote Web and&#44; subsequently&#44; to the Rayyan manager&#44; where the first phase was carried out&#44; with the reading of titles and abstracts&#46; The reading and selection steps were performed by two reviewers&#44; blindly&#46; In case of conflicts&#44; a third reviewer was called in&#46; The articles included in the first phase were read in full for the final selection&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The selected articles were analyzed regarding the study design&#44; sample&#44; characterization of the lingual frenulum and sleep assessment&#44; as well as the main results and conclusions&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The protocol registered in Prospero under number CRD42020206899&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 97 articles were identified&#46; After evaluating the duplicates&#44; 16 articles were excluded&#46; Thus&#44; the reviewers read 71 titles and abstracts in the first phase&#46; Of these&#44; 10 were included by both and 6 showed conflicts&#46; After the evaluation by the third reviewer&#44; 15 articles were included for full reading&#46; Of the 15 articles&#44; 11 were excluded by the authors for not meeting the inclusion criteria or for having a study design that met the exclusion criteria&#46; In the end&#44; four articles were included in the study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The article by Guilleminault et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> assessed 150 children aged 3&#8211;12 years in a retrospective study comparing children with a shortened lingual frenulum and children with a normal one&#46; To measure the lingual frenulum&#44; a measurement was taken during the maximum opening of the lower left incisor to the upper left incisor&#44; and then a measurement was taken with the mouth wide open with the tip of the tongue touching the incisor papilla&#46; This measure was considered normal if the difference between the two was &#60;50&#37;&#46; There was a statistical significance between the Apnea&#47;Hypopnea Index &#40;AHI&#41; of 13&#46;06&#8239;&#177;&#8239;4&#46;17 in the shortened lingual frenulum group <span class="elsevierStyleItalic">versus</span> 11&#46;36&#8239;&#177;&#8239;5&#46;39 in the normal lingual frenulum group &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;025&#41;&#46; The shortened lingual frenulum was predictive of a higher AHI in male &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;0069&#41;&#44; but not in female individuals &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;8615&#41;&#46; The study concluded that an untreated shortened lingual frenulum at birth is associated with OSAS at older age&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In another retrospective study&#44; Villa et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> assessed 504 children aged 6&#8211;14 years and evaluated subjective and objective criteria for OSAS&#44; using Kotlow&#8217;s criteria <a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> for measuring the lingual frenulum&#44; measuring the free length of the tongue &#40;the distance between the insertion of the lingual frenulum at the base of the tongue and the tip of the tongue&#41;&#44; considering the lingual frenulum to be shortened if the length were less than 16&#8239;mm&#46; In that study&#44; they concluded that of the 42 children at high risk for OSAS in a subjective assessment&#44; 18 &#40;42&#46;8&#37;&#41; had a shortened lingual frenulum&#44; and the incidence in the study was 114 patients &#40;22&#46;6&#37;&#41;&#46; In a multivariate logistic regression model&#44; the risk for OSAS in children with a shortened lingual frenulum was significantly higher than other possible factors&#44; such as obesity&#44; age&#44; gender&#44; and lingual tonus&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In the only prospective study included in this review&#44; Baxter et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> followed 37 children from 13 months to 12 years of age&#46; For the evaluation of the lingual frenulum&#44; Kotlow&#8217;s protocol was followed&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Twenty-four of them were snorers before being submitted to the lingual frenectomy&#44; of which 16 improved the snoring after the surgery&#46; The study concluded that&#44; in addition to improved sleep&#44; there was an improvement in speech and deglutition of solid foods&#44; as reported by parents&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In a retrospective cohort&#44; Zaghi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> followed individuals of all ages&#44; including 110 children&#46; The lingual frenulum was assessed using the lingual frenulum and tongue mobility scale&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> which includes a comparison of the measurements of maximum mouth opening and opening with the tip of the tongue on the palatine papilla&#44; considering a normal measurement when there is less than 50&#37; of difference between them&#46; The study concluded that lingual frenuloplasty with myofunctional therapy is safe and potentially effective for the treatment of mouth breathing&#44; snoring and myofascial tension&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">There is agreement between the four analyzed studies that the lingual frenulum alteration interferes with the growth of anatomical structures&#44; leading to alterations in respiratory&#44; suction&#44; chewing and speech functions&#46; Marchesan<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> reports that among the alterations caused by an altered lingual frenulum&#44; the most common are those related to speech&#44; nutrition&#44; with special attention to breastfeeding&#44; and deglutition functions&#46; There is a consensus in the literature that stomatognathic functions are affected by alterations in the lingual frenulum&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Considering the results found in the retrospective study by Guilleminault et al&#46;&#44; in which two groups were studied&#44; one with a shortened lingual frenulum and the other with a normal one&#44; where significant anatomical differences were observed between the two groups&#44; and the group with the shortened lingual frenulum had a high palate and maxillary atresia&#44; favoring airway collapsibility&#44; a question arises&#58; would early treatment have an effect&#44; improving the symptoms and potentially preventing the onset of a more severe picture of obstructive disorder&#63;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Zaghi et al&#46; published a retrospective cohort study aimed at exploring the safety and efficacy of lingual frenuloplasty and myofunctional therapy in patients with restricted tongue mobility&#46; A total of 348 patients who complained of one or more of the following symptoms were included&#58; mouth breathing &#40;n&#8239;&#61;&#8239;226&#41;&#44; snoring &#40;n&#8239;&#61;&#8239;151&#41;&#44; dysfunctional deglutition pattern &#40;n&#8239;&#61;&#8239;130&#41;&#44; myofascial tightness &#40;n&#8239;&#61;&#8239;44&#41; and&#47;or pain or tension &#40;n&#8239;&#61;&#8239;151&#41; and who were treated with lingual frenuloplasty and myofunctional therapy&#46; Anterior lingual frenectomy was performed in 41 of the patients &#40;11&#46;7&#37;&#41;&#44; with complementation elsewhere when persistent restrictions in tongue mobility were identified&#46; A myofunctional therapy protocol was performed one month preoperatively and two months after lingual frenectomy&#46; Pain severity and complications were rated on a 10-point visual analogue scale&#46; Changes in overall health-related quality of life and overall satisfaction were assessed using the Likert Scale&#46; Snoring complaints and sleep quality were also assessed with the abovementioned scales&#44; with no nocturnal monitoring exam being performed&#46; The results obtained were an 87&#37; improvement in quality of life through improved mouth breathing &#40;78&#46;4&#37;&#41;&#44; snoring &#40;72&#46;9&#37;&#41;&#44; teeth clenching &#40;91&#46;0&#37;&#41; and&#47;or myofascial tension &#40;77&#46;5&#37;&#41;&#46; The authors affirm that lingual frenuloplasty associated with myofunctional therapy is safe and potentially effective for the treatment of mouth breathing&#44; snoring and myofascial tension&#44; and further studies are required to identify the ideal candidates for this treatment&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Baxter et al&#46; in 2020 published a prospective study of lingual frenectomy carried out with LightScalpel CO<span class="elsevierStyleInf">2</span> laser&#44; followed by myofunctional therapy carried out in 37 patients &#40;mean age 4&#46;2 years&#44; ranging from 13 months to 12 years&#41;&#44; of which 62&#37; were boys and 38&#37; girls&#46; The degree of lingual mobility restriction was assessed using Kotlow&#8217;s classification scale&#46; The study comprised the assessment of speech&#44; eating&#44; sleep&#44; and other related symptoms reported on a yes&#47;no basis&#46; The results observed in the first week were that 76&#37; of the parents reported an improvement in speech&#44; 69&#37; observed an improvement in feeding and 85&#37; observed that their children&#39;s sleep improved&#46; Within one month&#44; 89&#37; of parents reported improved speech&#44; 83&#37; observed improved feeding&#44; and 83&#37; witnessed improved sleep&#46; According to the reports&#44; the children slept less frequently in awkward positions &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; kicked and moved less at night &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#46; They slept more soundly &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; woke up less tired &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; had less teeth grinding &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; less mouth breathing &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; and less snoring &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#46; Interestingly&#44; additional changes were observed by parents&#44; as children reported less neck pain &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;031&#41;&#44; less headaches &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;008&#41;&#44; less vomiting reflex &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; less mouth breathing &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; less reflux &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;002&#41;&#44; less hyperactivity and inattention &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;001&#41;&#44; and less constipation &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;004&#41;&#46; The authors stated that these results should encourage health professionals who treat children with speech&#44; eating and sleep disorders to assess possible tongue mobility restrictions in these patients&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In 2020&#44; Villa et al&#46; carried out a study with the aim of evaluating the presence of a shortened lingual frenulum as a risk factor for the development of sleep-disordered breathing &#40;SDB&#41; in school-age children&#44; whether or not they were snorers&#46; A total of 504 children were included&#44; aged between 6 and 14 years&#44; who were evaluated using a clinical tool used in the detection of children at high risk for SDB&#44; called sleep clinical record &#40;SCR&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> The total SCR score is calculated considering nasal&#44; oropharynx&#44; dental&#44; craniofacial and occlusion abnormalities&#46; A total SCR score greater than or equal to 6&#46;5 is considered to be positive and associated with a high risk of OSA&#44; defined as an obstructive apnea&#47;hypopnea index &#40;AHI&#41; &#62;1 episode&#47;h&#46; Of the 504 children evaluated in this study&#44; 42 &#40;8&#46;3&#37;&#41; were at high risk for OSA&#44; as indicated by an SCR score &#62;6&#46;5&#46; Of these children&#44; 18 &#40;42&#46;8&#37;&#41; had a shortened lingual frenulum&#46; Among all 504 children&#44; a shortened lingual frenulum was found in 114 &#40;22&#46;6&#37;&#41;&#46; The multivariate logistic regression model showed that children with a shortened lingual frenulum had a significantly higher risk for a positive SCR and&#44; therefore&#44; a greater risk for developing OSA&#44; when compared to those with a normal lingual frenulum and that this higher risk was more significant even when other factors that can possibly affect the risk of OSA &#40;age&#44; gender&#44; tongue strength&#44; obesity&#41; were taken into account&#46; The authors concluded that an association between a shortened lingual frenulum and SDB was demonstrated&#44; and that a multidisciplinary approach is required to allow the early detection and timely treatment of craniofacial changes and potentially prevent SDB&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The studies by Zaghi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> and Baxter et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> showed that the association of myofunctional therapy with lingual frenectomy brought benefits to treated patients&#44; showing the importance of a multidisciplinary action&#46; In a study carried out in 2016 with 101 patients&#44; Ferr&#233;s-Amat et al&#46; submitted 96&#37; of patients to the myofunctional therapy&#44; starting one week before performing the lingual frenectomy&#44; aiming at increasing lingual mobility and reducing pain&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The four studies show significance in the relationship between the lingual frenulum alteration and OSA&#46; Further studies with surgical intervention are needed&#44; as well as polysomnographic examinations before and after lingual frenectomy in a larger sample of the population&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0160" class="elsevierStylePara elsevierViewall">The results of these studies suggest that speech&#44; mastication&#44; breathing and sleep can be affected by a tongue with restricted mobility&#44; and that its adequate surgical release associated with myofunctional therapy can result in functional and quality of life improvement&#46; The improvement in sleep quality was significant in patients included in the studies&#44; in which the intervention was performed&#44; because&#44; after the intervention&#44; the tongue was able to rest on the palate instead of resting on the floor of the mandible&#46; The possibility of tongue elevation&#44; and the releasing of the restriction so that the elevation normalizes&#44; is the reason for the observed improvement&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The studies included in the present review corroborate the association between ankyloglossia and obstructive sleep apnea&#46;</p><p id="par0161" class="elsevierStylePara elsevierViewall">This article is part of the master&#39;s thesis of the Surgery Sciences Program at the Faculty of Medical Sciences of the State University of Campinas &#40;UNICAMP&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Funding</span><p id="par0170" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of interest</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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    "highlights" => array:2 [
      "titulo" => "Highlights"
      "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0005" class="elsevierStylePara elsevierViewall">An untreated shortened lingual frenulum at birth is associated with sleep apnea&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0010" class="elsevierStylePara elsevierViewall">A shortened lingual frenulum alters the craniofacial growth with respiratory consequences&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Lingual frenuloplasty associated with myofunctional therapy is effective in the treatment of snoring&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0020" class="elsevierStylePara elsevierViewall">In addition to improved sleep&#44; there was an improvement in the speech and deglutition functions&#46;</p></li></ul></p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To investigate the evidence on the association between ankyloglossia and obstructive sleep apnea&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">An integrative literature review was carried out in the databases&#46; Observational and interventional studies that assessed the lingual frenulum in children with sleep-disordered breathing were included&#46; As exclusion criteria&#58; studies in animals&#44; <span class="elsevierStyleItalic">in vitro</span>&#44; letters to the editor&#44; expert opinions&#44; other reviews&#46; The selected articles were analyzed regarding the study design&#44; sample&#44; characterization of the lingual frenulum and sleep assessment&#44; in addition to the main results and conclusions&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ninety-seven articles were identified&#44; but only 4 met the inclusion criteria&#46; Two retrospective studies concluded that the untreated shortened lingual frenulum at birth is associated with obstructive sleep apnea&#46; A prospective study concluded that there was an improvement in speech and deglutition after lingual frenectomy&#44; in addition to improved sleep&#46; A retrospective cohort concluded that lingual frenuloplasty combined with myofunctional therapy is effective in the treatment of snoring and mouth breathing&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The studies included in this review contribute to corroborate the association between ankyloglossia and obstructive sleep apnea&#46;</p></span>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PECOS</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">P</span></span><span class="elsevierStyleItalic">articipants</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">E</span></span><span class="elsevierStyleItalic">xposition</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obstructive sleep apnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">C</span></span><span class="elsevierStyleItalic">omparison</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No comparison&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">O</span></span><span class="elsevierStyleItalic">utcomes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Studies that performed the assessment of the lingual frenulum&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Types of</span><span class="elsevierStyleBold"><span class="elsevierStyleItalic">S</span></span><span class="elsevierStyleItalic">tudies</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Observational and interventional studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            ]
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Database&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Search&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Initial findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pubmed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; &#91;MeSH Terms&#93; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; &#91;MeSH Terms&#93; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; &#91;MeSH Terms&#93; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scopus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Embase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8216;sleep apnea&#44; obstructive&#8217;&#47;exp OR &#8216;sleep apnea&#44; obstructive&#8217; OR &#8216;apneas&#44; obstructive sleep&#8217; OR &#8216;obstructive sleep apneas&#8217; OR &#8216;sleep apneas&#44; obstructive&#8217; OR &#8216;obstructive sleep apnea syndrome&#8217;&#47;exp OR &#8216;obstructive sleep apnea syndrome&#8217; OR &#8216;obstructive sleep apnea&#8217;&#47;exp OR &#8216;obstructive sleep apnea&#8217; OR &#8216;osahs&#8217; OR &#8216;syndrome&#44; sleep apnea&#44; obstructive&#8217; OR &#8216;sleep apnea syndrome&#44; obstructive&#8217; OR &#8216;apnea&#44; obstructive sleep&#8217; OR &#8216;sleep apnea hypopnea syndrome&#8217;&#47;exp OR &#8216;sleep apnea hypopnea syndrome&#8217; OR &#8216;syndrome&#44; obstructive sleep apnea&#8217; OR &#8216;upper airway resistance sleep apnea syndrome&#8217; OR &#8216;syndrome&#44; upper airway resistance&#44; sleep apnea&#8217; OR &#8216;osa&#8217; OR &#8216;osas&#8217; OR &#8216;sleep apnea syndromes&#8217;&#47;exp OR &#8216;sleep apnea syndromes&#8217; OR &#8216;apnea syndrome&#44; sleep&#8217; OR &#8216;apnea syndromes&#44; sleep&#8217; OR &#8216;sleep apnea syndrome&#8217;&#47;exp OR &#8216;sleep apnea syndrome&#8217; OR &#8216;sleep hypopnea&#8217; OR &#8216;hypopnea&#44; sleep&#8217; OR &#8216;hypopneas&#44; sleep&#39; OR &#8216;sleep hypopneas&#8217; OR &#8216;apnea&#44; sleep&#8217;&#47;exp OR &#8216;apnea&#44; sleep&#8217; OR &#8216;apneas&#44; sleep&#8217; OR &#8216;sleep apnea&#8217;&#47;exp OR &#8216;sleep apnea&#8217; OR &#8216;sleep apneas&#8217; OR &#8216;sleep apnea&#44; mixed central and obstructive&#8217; OR &#8216;mixed central and obstructive sleep apnea&#8217; OR &#8216;sleep apnea&#44; mixed&#8217; OR &#8216;mixed sleep apnea&#8217; OR &#8216;mixed sleep apneas&#8217; OR &#8216;sleep apneas&#44; mixed&#8217; OR &#8216;hypersomnia with periodic respiration&#8217; OR &#8216;sleep-disordered breathing&#8217;&#47;exp OR &#8216;sleep-disordered breathing&#8217; OR &#8216;breathing&#44; sleep-disordered&#8217; OR &#8216;sleep disordered breathing&#8217;&#47;exp OR &#8216;sleep disordered breathing&#8217;&#41; AND &#40;&#8216;lingual frenum&#8217;&#47;exp OR &#8216;lingual frenum&#8217; OR &#8216;lingual frenulum&#8217;&#47;exp OR &#8216;lingual frenulum&#8217; OR &#8216;frenulum&#44; lingual&#8217;&#47;exp OR &#8216;frenulum&#44; lingual&#8217; OR &#8216;frenulums&#44; lingual&#8217; OR &#8216;lingual frenulums&#8217; OR &#8216;frenum&#44; lingual&#8217; OR &#8216;frenums&#44; lingual&#8217; OR &#8216;lingual frenums&#8217;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Web of Science&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lilacs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221; OR &#8220;Apneia Obstrutiva do Sono&#8221; OR &#8220;Apneia do Sono Obstrutiva&#8221; OR &#8220;Apneia do Sono Tipo Obstrutiva&#8221; OR &#8220;S&#237;ndrome da Apneia Obstrutiva do Sono&#8221; OR &#8220;S&#237;ndrome de Apneia do Sono por Resist&#234;ncia das Vias A&#233;reas Superiores&#8221; OR &#8220;Apnea Obstructiva del Sue&#241;o&#8221; OR &#8220;S&#237;ndromes da Apneia do Sono&#8221; OR &#8220;Apneia do Sono&#8221; OR &#8220;Hipersonia com Respira&#231;&#227;o Peri&#243;dica&#8221; OR &#8220;Respira&#231;&#227;o Desordenada Durante o Sono&#8221; OR &#8220;S&#237;ndromes de la Apnea del Sue&#241;o&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221; OR &#8220;Freio Lingual&#8221; OR &#8220;Frenillo Lingual&#8221; OR &#8220;Fr&#234;nulo da L&#237;ngua&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ProQuest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8220;Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Apneas&#44; Obstructive Sleep&#8221; OR &#8220;Obstructive Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Obstructive&#8221; OR &#8220;Obstructive Sleep Apnea Syndrome&#8221; OR &#8220;Obstructive Sleep Apnea&#8221; OR &#8220;OSAHS&#8221; OR &#8220;Syndrome&#44; Sleep Apnea&#44; Obstructive&#8221; OR &#8220;Sleep Apnea Syndrome&#44; Obstructive&#8221; OR &#8220;Apnea&#44; Obstructive Sleep&#8221; OR &#8220;Sleep Apnea Hypopnea Syndrome&#8221; OR &#8220;Syndrome&#44; Obstructive Sleep Apnea&#8221; OR &#8220;Upper Airway Resistance Sleep Apnea Syndrome&#8221; OR &#8220;Syndrome&#44; Upper Airway Resistance&#44; Sleep Apnea&#8221; OR &#8220;OSA&#8221; OR &#8220;OSAS&#8221; OR &#8220;Sleep Apnea Syndromes&#8221; OR &#8220;Apnea Syndrome&#44; Sleep&#8221; OR &#8220;Apnea Syndromes&#44; Sleep&#8221; OR &#8220;Sleep Apnea Syndrome&#8221; OR &#8220;Sleep Hypopnea&#8221; OR &#8220;Hypopnea&#44; Sleep&#8221; OR &#8220;Hypopneas&#44; Sleep&#8221; OR &#8220;Sleep Hypopneas&#8221; OR &#8220;Apnea&#44; Sleep&#8221; OR &#8220;Apneas&#44; Sleep&#8221; OR &#8220;Sleep Apnea&#8221; OR &#8220;Sleep Apneas&#8221; OR &#8220;Sleep Apnea&#44; Mixed Central and Obstructive&#8221; OR &#8220;Mixed Central and Obstructive Sleep Apnea&#8221; OR &#8220;Sleep Apnea&#44; Mixed&#8221; OR &#8220;Mixed Sleep Apnea&#8221; OR &#8220;Mixed Sleep Apneas&#8221; OR &#8220;Sleep Apneas&#44; Mixed&#8221; OR &#8220;Hypersomnia with Periodic Respiration&#8221; OR &#8220;Sleep-Disordered Breathing&#8221; OR &#8220;Breathing&#44; Sleep-Disordered&#8221; OR &#8220;Sleep Disordered Breathing&#8221; OR &#8220;Apneia Obstrutiva do Sono&#8221; OR &#8220;Apneia do Sono Obstrutiva&#8221; OR &#8220;Apneia do Sono Tipo Obstrutiva&#8221; OR &#8220;S&#237;ndrome da Apneia Obstrutiva do Sono&#8221; OR &#8220;S&#237;ndrome de Apneia do Sono por Resist&#234;ncia das Vias A&#233;reas Superiores&#8221; OR &#8220;Apnea Obstructiva del Sue&#241;o&#8221; OR &#8220;S&#237;ndromes da Apneia do Sono&#8221; OR &#8220;Apneia do Sono&#8221; OR &#8220;Hipersonia com Respira&#231;&#227;o Peri&#243;dica&#8221; OR &#8220;Respira&#231;&#227;o Desordenada Durante o Sono&#8221; OR &#8220;S&#237;ndromes de la Apnea del Sue&#241;o&#8221;&#41; AND &#40;&#8220;Lingual Frenum&#8221; OR &#8220;Lingual Frenulum&#8221; OR &#8220;Frenulum&#44; Lingual&#8221; OR &#8220;Frenulums&#44; Lingual&#8221; OR &#8220;Lingual Frenulums&#8221; OR &#8220;Frenum&#44; Lingual&#8221; OR &#8220;Frenums&#44; Lingual&#8221; OR &#8220;Lingual Frenums&#8221; OR &#8220;Freio Lingual&#8221; OR &#8220;Frenillo Lingual&#8221; OR &#8220;Fr&#234;nulo da L&#237;ngua&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Search performed in the databases and the respective initial results&#46;</p>"
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ISSN: 18088694
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