Journal Information
Vol. 89. Issue 3.
Pages 359-512 (May - June 2023)
Why we shouldn’t think about percentages or rate loss when it comes to hearing impairment
José Fernando Polanski, Arthur Menino Castilho
Braz J Otorhinolaryngol. 2023;89:511-2
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Original articles
Transcutaneous injection of triamcinolone acetonide for persistent glottic granulation after laser microsurgery
Ying Zhang, Shisheng Li
Braz J Otorhinolaryngol. 2023;89:359-65

  • Persistent granulation could not disappear after conservative treatment.

  • Reoperation was not recommended.

  • Triamcinolone Acetonide (TA) injection in vocal fold is mature.

  • TA could accelerate the disappear of granulation or persistent granulation.

  • Suitable for huge granulation which blocks the glottis and the recur.

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The development of nasal polyps involves early middle meatus mucous remodeling via TGF-β1 mediated PAI-1 reduction
Yijun Liu, Longlan Shu, Xiaocong Jiang, Yue Zhang, Qian Chen, Yang Shen, Yucheng Yang
Braz J Otorhinolaryngol. 2023;89:366-73

  • We have investigated the fibrosis genes in the TGF-β pathway in the early and mature nasal polyps development process, respectively.

  • PAI-1 is involved in early nasal polyps, and its low fibrolysis is predisposed to nasal polyps’ development.

  • PAI-1 is affected by the TGF pathway, and low PAI-1 expression is one of the main reasons for tissue remodeling in nasal polyps.

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The effect of primary tumor volume on the prognosis of nasopharyngeal carcinoma in era of volumetric modulated arc therapy: a propensity score matched cohort study
Xiang Lin, Bingyi Wang, Fei Zheng, Zhaodong Fei, Chuanben Chen
Braz J Otorhinolaryngol. 2023;89:374-82

  • Propensity score matching was used to reduce bias in the study.

  • PTV was an important independent predictor on survival for NPC patients receiving VMAT.

  • PTV > 38 mL may be considered as an indicator of the clinical stage of nasopharyngeal carcinoma.

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MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase
Hailin Chen, Xuwei Cai, Baowen Du, Jianpiao Cai, Zhengzheng Luo
Braz J Otorhinolaryngol. 2023;89:383-92

  • MiR-150-5p is down-regulated in Laryngeal Squamous Cell Carcinoma (LSCC).

  • PIN1 is a target gene of miR-150-5p.

  • MiR-150-5p inhibits the proliferation and invasion of LSCC cells by targeting PIN1.

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Exploration of the heterogeneity and interaction of epithelial cells and NK/T-cells in Laryngeal Squamous Cell Carcinoma based on single-cell RNA sequencing data
Yanan Liu, Zhiguang Gao, Cheng Peng, Xingli Jiang
Braz J Otorhinolaryngol. 2023;89:393-400

  • Characterized the heterogeneity of LSCC, which provided novel insights into LSCC.

  • Igand-receptor interactions of epithelial and NK/T-cells to identify a new mechanism.

  • CNTN2 might be a novel biomarker for LSCC.

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The role and clinical significance of microRNA-29a-3p in the development of hypopharyngeal carcinoma
Tao Liu, Detao Ding, Wei Wang, Yungang Wu, Dengdian Ma, Miaomiao Liu, Ziqiao Tan, Jing Yao, Xiaoyu Li
Braz J Otorhinolaryngol. 2023;89:401-9

  • The results showed that microRNA-29a-3p expression was relatively high in non-cancer tissue cells but was relatively low in cancer tissue.

  • Some clinicopathologic features, the expression of Ki67 and E-cadherin, and the survival time of HPC patients were correlated with miRNA-29a-3p.

  • This study found the relationship between miRNA-29a-3p and the occurrence and development of HPC.

  • This study will contribute to the individualized treatment of HPC, which improve the treatment strategy and prognosis evaluation system of HPC.

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Comparative study of the effectiveness of the surgical technique with and without preservation of the conchal cartilage in otoplasty through the measure of the cephalo-auricular and scapho-conchal angles
Caio Marcio Correia Soares, Flávia David João De Masi Nassif, Daniela Dranka, Renata Vecentin Becker, Johann Melcherts Hurtado, Renato da Silva Freitas
Braz J Otorhinolaryngol. 2023;89:410-6

  • Protruding ear can causes low self-esteem, leading patients to undergone otoplasty.

  • Otoplasty with or without conchal preservation significantly reduce the deformity.

  • Careful analysis of the auricular deformity to choose the best surgical technique.

  • Eclectic technique with conchal remaining suture is effective for ear correction.

  • No significant difference between otoplasty with and without conchal preservation.

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Prognostic and predictive role of soluble programmed death ligand-1 in head and neck cancer
Maria Molga-Magusiak, Anna Rzepakowska, Michał Żurek, Iwona Kotuła, Urszula Demkow, Kazimierz Niemczyk
Braz J Otorhinolaryngol. 2023;89:417-24

  • sPD-L1 is potential predictive biomarker for differentiation of malignant lesions in head and neck region.

  • Significantly higher levels of sPD-L1 are detected in malignant tumors.

  • Higher levels of sPD-L1 proves reliable prognostic biomarker in predicting early recurrence of laryngeal cancer.

  • Increased sPD-L1 correlates with poor disease-free survival in head and neck cancer.

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Associated oral manifestations with HIV southeastern Brazilian patients on antiretroviral therapy
Brisa Ketrine Lustosa de Souza, Daniele Sorgatto Faé, Cleidiel Aparecido Araújo Lemos, Francielle Silvestre Verner, Renato Assis Machado, Rose Mara Ortega, Sibele Nascimento de Aquino
Braz J Otorhinolaryngol. 2023;89:425-31

  • The associated oral manifestations in HIV patients remain present even in the HAART era.

  • Periodontal disease with or without mobility were the predominant oral lesions in the patients of this study.

  • No relationship was found between oral lesions, TCD4+ and TCD8+ cell count, TCD4:TCD8 ratio, or viral load.

  • There is a protective effect of duration of treatment with relation to periodontal disease with mobility.

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Combination of Merocel sponge with Lipopolysaccharide to establish rat rhinosinusitis model
Mengmeng Sun, Junjie Yang, Jiayu Liu, Ming Jing, Leiming Zhang, Wenyu Xin
Braz J Otorhinolaryngol. 2023;89:432-9

  • For the first time, a rat rhinosinusitis model was established using LPS and Merocel sponge.

  • LPS can induce nasal inflammation through TLR4 signaling pathway.

  • LPS can reduce AQP5, occludin protein expression.

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Treatment outcomes of alternating chemoradiotherapy for nasopharyngeal carcinoma: a single-center safety and efficacy study
Kenzo Ohara, Miki Takahara, Takumi Kumai, Masaaki Yamashina, Kan Kishibe, Akihiro Katada, Tatsuya Hayashi
Braz J Otorhinolaryngol. 2023;89:440-6

  • The safety and efficacy of alternating chemoradiotherapy using cisplatin and 5-fluorouracil were retrospectively examined in nasopharyngeal carcinoma patients.

  • The overall comlete response rate was 93% with preserving renal function.

  • The 5-year overall survival and progression-free survival rates were 83.7% and 88.9%, respectively.

  • Treatment compliance, the 5-year overall survival rate and the 5-year overall survival rate are comparable to that of previous reports.

  • Alternating chemoradiotherapy using cisplatin and 5-fluorouracil in nasopharyngeal carcinoma patients was well tolerated with acceptable efficacy.

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Algorithm for pediatric orbital blowout fractures: a 20-year retrospective cohort study
Kosuke Takabayashi, Yohei Maeda, Nobuya Kataoka, Hiroyuki Kagokawad, Masayoshi Nagaminea, Isao Otad, Taketoshi Fujita
Braz J Otorhinolaryngol. 2023;89:447-55

  • Develop a treatment algorithm for pediatric orbital blowout fractures.

  • Findings to consider urgent release for linear type of pediatric orbital blowout fractures: missing rectus and OCR.

  • Present the results using the Hess area ratio, an objective measure of treatment outcome.

  • Simple algorithm easily used even for physicians who do not specialize in orbital care.

  • Algorithm producing successful treatment outcomes.

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Impact of the COVID-19 Pandemic on Brazilian Head and Neck Surgery Centers
Gustavo Fernandes de Alvarenga, Ana Kober Nogueira Leite, Carlos Neutzling Lehn, Rogério Aparecido Dedivitis, Marianne Yumi Nakai, Beatriz Godoi Cavalheiro, Gilberto Vaz Teixeira, Rafael De Cicco, ... Leandro Luongo de Matos
Braz J Otorhinolaryngol. 2023;89:456-61

  • The total number of diagnostic exams and surgical procedures had decreased significantly.

  • Surgery for head and neck cancer treatment increased in the total surgical logbook.

  • Most residents faced reduction in surgical logbook and deployment to COVID-19 facilities.

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Effect of tinnitus on sound localization ability in patients with normal hearing
Yue Long, Wei Wang, Jiao Liu, Ke Liu, Shusheng Gong
Braz J Otorhinolaryngol. 2023;89:462-8

  • Tinnitus is a common disorder that affects hearing and social interactions.

  • Patients with tinnitus have reported hearing difficulties in noisy environments.

  • Tinnitus negatively impacts sound source localization in those with normal hearing.

  • It might also affect the processing of brain cues for sound source discrimination.

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cAMP-Epac1 signaling is activated in DDAVP-induced endolymphatic hydrops of guinea pigs
Wang Chuan, Li Yuan, Jiang Wen, Zeng Jianwei, Wang Caiji, Zhao Zeqi, Li Yalan, Ji Renlong, ... Li Xuanyi
Braz J Otorhinolaryngol. 2023;89:469-76

  • This work aims to explore whether cAMP-Epac1 signaling is also activated.

  • We verified the differential expression of Epac1 and Epac2 in the inner ear of guinea pigs with endolymphatic hydrops.

  • The results of this study showed DDAVP upregulated Epac1 protein expression in the guinea pig cochlea.

  • The article laid a theoretical foundation for further investigation on how DDAVP regulates endolymphatic metabolism to induce EH and affect inner ear function.

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Changes in brain gray matter volume in nasopharyngeal carcinoma patients after radiotherapy in long-term follow-up
Wenjia Zhu, Fu Chen, Dongming Yin, Keguang Chen, Shengzi Wang
Braz J Otorhinolaryngol. 2023;89:477-84

  • The change in brain gray matter volume in NPC patients after radiotherapy in long-term follow-up were studied.

  • NPC patients with the radiation-induced hearing loss had abnormal brain gray matter volume in the auditory center and other sensory centers.

  • Our findings might provide new understanding into the pathogenesis of radiation-induced brain damage in normal-appearing brain tissue.

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Subjective Visual Vertical and Vestibular Evoked Myogenic Potential in Meniere's disease
Maristela Mian Ferreira, Karen de Carvalho Lopes, Thaís Alvares de Abreu e Silva Grigol, Maurício Malavasi Ganança, Heloisa Helena Caovilla
Braz J Otorhinolaryngol. 2023;89:485-93

  • SVV test evaluates the static otolith system and, cervical and ocular VEMPs, examines the dynamic.

  • SVV, with the bucket method, and cervical and ocular VEMPs, contribute to the assessment of vestibulopathies.

  • SVV and cervical and ocular VEMPs together, are advantageous to assess otolith disorders in Meniere’s disease.

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Review articles
Rapid maxillary expansion in pediatric patients with obstructive sleep apnea: an umbrella review
Denise Fernandes Barbosa, Laura Fernandes Bana, Maria Cristina Buta Michel, Miguel Meira e Cruz, Edilson Zancanella, Almiro José Machado Júnior
Braz J Otorhinolaryngol. 2023;89:494-502

  • The studies of rapid maxillary expansion in obstructive sleep apnea children's treatment are based on low-quality evidence.

  • Management decisions should be linked to the phenotype, considering outcomes beyond the apnea-hypopnea index.

  • A health policy is needed focusing on respiratory disorders prevention.

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Is maxillomandibular advancement an effective treatment for obstructive sleep apnea? Systematic literature review and meta-analysis
Paulo Alceu Kiemle Trindade, Vânia dos Santos Nunes Nogueira, Silke Anna Theresa Weber
Braz J Otorhinolaryngol. 2023;89:503-10

  • Maxillomandibular advancement for obstructive sleep apnea treatment.

  • Volumetric alterations of the upper airways in orthognathic surgery.

  • Apnea and Hypopnea Index reduction after maxillomandibular advancement.

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Brazilian Journal of Otorhinolaryngology (English Edition)
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Articles submitted as of May 1, 2022, which are accepted for publication will be subject to a fee (Article Publishing Charge, APC) payment by the author or research funder to cover the costs associated with publication. By submitting the manuscript to this journal, the authors agree to these terms. All manuscripts must be submitted in English.. Os artigos submetidos a partir de 1º de maio de 2022, que forem aceitos para publicação estarão sujeitos a uma taxa (Article Publishing Charge, APC) a ser paga pelo autor para cobrir os custos associados à publicação. Ao submeterem o manuscrito a esta revista, os autores concordam com esses termos. Todos os manuscritos devem ser submetidos em inglês.