Journal Information
Issue
Vol. 91. Issue 1.
(January - February 2025)
Editorials
Photobiomodulation in Brazil: Current scenario and evidence-based practice in the voice clinic
Gustavo Polacow Korn, Renata Rangel Azevedo, Viviane Souza Bicalho Bacelete, Claudia Alessandra Eckey
Braz J Otorhinolaryngol. 2025;91:101543
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Original articles
Evaluation of mastoid volume and dimensions in unilateral microtia patients: retrospective study using High Resolution Computed Tomography (HRCT)
Trimartani Koento, Anita Amalia Sari, Mirta Hediyati Reksodiputro, Harim Priyono, Semiramis Zizlavsky, Reyhan Eddy Yunus, Joedo Prihartono, Mikhael Yosia
Braz J Otorhinolaryngol. 2025;91:101501
Highlights

  • Reduced mastoid volumes in microtia ears offer novel anatomical insights.

  • Microtia ears show smaller mastoid height and area at specific levels.

  • Data aids in preoperative counselling and technique selection.

  • HRCT valuable for precise mastoid anatomy evaluation in microtia.

  • Mastoid variations crucial for optimal microtia surgical outcomes.

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Profile of oropharyngeal swallowing in healthy Brazilian adults and older adults
Giovana Piovesan Dall'Oglio, Eliézia Helena De Lima Alvarenga, Leonardo Haddad, Mateus Morais Aires, Márcio Abrahão
Braz J Otorhinolaryngol. 2025;91:101494
Highlights

  • Age ≥80 years linked to higher salivary stasis and residue.

  • FEES reveals no age impact on penetration and aspiration.

  • Number of swallows to clear bolus was two during lifespan.

  • The swallowing reflex was triggered up to the vallecula in 99% in all consistencies.

  • Presence of residue and penetration indicate impaired swallowing efficiency and safety.

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Development of the TP53 mutation associated hypopharyngeal squamous cell carcinoma prognostic model through bulk multi-omics sequencing and single-cell sequencing
Ying Zhang, Yue Cui, Congfan Hao, Yingjie Li, Xinyang He, Wenhui Li, Hongyang Yu
Braz J Otorhinolaryngol. 2025;91:101499
Highlights

  • The HPSCC prognostic model of TP53 mutation was constructed via POLD2 and POLR2G.

  • Risk scores from the model were associated with cancer conditions and immune infiltration.

  • Higher expression cells of POLD2, POLR2G, and metabolism pathways were analyzed.

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Hearing results following endoscopic type I tympanoplasty in medium and large perforations
Lihua Yue, Xiao Liu, Hongyan Liu, Haina Ma
Braz J Otorhinolaryngol. 2025;91:101509
Highlights

  • Chronic otitis media leads to tympanic membrane perforation and hearing impairment.

  • Endoscopic ear surgery has the advantages of minimally invasive.

  • Endoscopic type I tympanoplasty yield satisfactory hearing results in patients with medium to large tympanic membrane perforations.

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Evaluation of epithelial-to-mesenchymal transition and Ki-67 index in aggressive papillary thyroid cancer
Luana Perrone Camilo, Paula Vianna, Venancio Avancini Ferreira Alves, Beatriz Godoi Cavalheiro, Carlos Augusto Rossetti, Luiz Paulo Kowalski, Leandro Luongo Matos, Ana Kober Nogueira Leite
Braz J Otorhinolaryngol. 2025;91:101510
Highlights

  • Despite being rare, death from the progression of papillary thyroid cancer occurs.

  • Factors associated with this outcome are not completely understood.

  • Ki-67 expression >11% was associated with death from the disease.

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Correlation between vestibular response to caloric stimulation and cochlear function in Ménière's disease
da Rosa Heinen Leticia, Assis Moro da Rocha Filho Marcelo, Zanelatto Santos Artur, Calage Pinto Amanda, Afonso de Freitas Toledo Samuel, Lavinsky Luiz, Lavinsky Joel
Braz J Otorhinolaryngol. 2025;91:101513
Highlights

  • The study has a moderate correlation of the caloric test and four-frequency average.

  • Between grades I and II, there was a greater impact on caloric tests in grade I.

  • The cochlear damage was directly proportional to the vestibular deficit.

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Translation, adaptation, and validation of ASK nasal-12 into Brazilian Portuguese
Jeniffer Cristina Kozechen Rickli, Ricardo Landini Lutaif Dolci, Leandro Meira Martins, Miguel Bosenbecker Böhm, Dino Rafael Perez, Américo Rubens Leite dos Santos, Paulo Roberto Lazarini
Braz J Otorhinolaryngol. 2025;91:101511
Highlights

  • A prospective longitudinal observational study.

  • Translate, adapt, and validate ASK Nasal-12 to Brazilian Portuguese.

  • The final translated version was validated with the SNOT-22 questionnaire.

  • Specific questionnaire to anterior skull base endonasal surgery.

  • Assessment of QOL after skull base endonasal surgery is essential.

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Serum HOTTIP expression is upregulated in nasopharyngeal carcinoma patients and predicts poor prognosis
Ding-Ting Wang, Jian Luo, Hua-Jun Feng, Yuan-Yuan Wang
Braz J Otorhinolaryngol. 2025;91:101471
Highlights

  • HOTTIP was highly expressed in the serum of Nasopharyngeal Carcinoma (NPC).

  • HOTTIP expression were related to the PFS and OS of NPC patients.

  • High HOTTIP expression was an independent risk factor for PFS in NPC patients

  • HOTTIP promoted the proliferation of NPC cells and inhibited cells apoptosis.

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Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma
Gaofei Yin, Wei Guo, Rong Wang, Nuan Li, Xiaohong Chen, Yang Zhang, Zhigang Huang
Braz J Otorhinolaryngol. 2025;91:101484
Highlights

  • Using databases to analyze IL-1 and related genes for their relevance in HNSCC.

  • We found IL18RAP and SIGIRR are highly expressed in HPV+ tumors.

  • IL18RAP, IL36A and SIGIRR were found to be prognostic protective factors.

  • IL-1A, IL1RAP, IL18RAP and SIGIRR affect the prognosis by CD8+ T-cell infiltration.

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Pre-clinical training, technical adjustment and human case experience of transoral robotic surgery using Versius System
Guilherme Reimann Agne, Gustavo Nunes Bento, Marcelo Belli, Gustavo Becker Pereira, Renan Bezerra Lira, Leandro Luongo Matos, Luiz Paulo Kowalski
Braz J Otorhinolaryngol. 2025;91:101515
Highlights

  • Transoral Robotic Surgery is well-established using the DaVinci system.

  • Transoral robotic surgery with the Versius System is currently in its initial stage.

  • A mannequin model was effective for training and setup configuration.

  • The first human case demonstrated feasibility and excellent results.

  • In our preliminary experience, Versius proved to be a promising robotic system.

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Review articles
Effect of suppression of otoacoustic emissions in individuals with and without central auditory processing disorder: a systematic review
Jéssica Dayane da Silva, Mariana de Carvalho Leal Gouveia, Laís Cristine Delgado da Hora, Leonardo Gleygson Ângelo Venancio, Lilian Ferreira Muniz
Braz J Otorhinolaryngol. 2025;91:101485
Highlights

  • Different results of TEOAE suppression tests in individuals with and without CAPD.

  • It is suggested to standardize the measurement and analysis parameters of the exam.

  • Studies that modify parameters and reduce responses of different nature than MOC.

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Importance of psychological follow-up in rhinoplasty
Thales Victor Fernandes Ferreira, Ana Luíza Cézar Fernandes, Mário Pinheiro Espósito
Braz J Otorhinolaryngol. 2025;91:101498
Highlights

  • Preoperative Emotional Support Manages anxiety and sets realistic expectations.

  • Boosts Self-Image and Esteem Improves mental health and patient satisfaction.

  • Enhances Postoperative Recovery Helps adapt to changes and cope with recovery.

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V Brazilian Consensus on Rhinitis – 2024
Dirceu Solé, Fábio Chigres Kuschnir, Antônio Carlos Pastorino, Clóvis F. Constantino, Clóvis Galvão, Débora Carla Chong e Silva, Eduardo Baptistella, Ekaterini Simões Goudouris, ... João Ferreira de Mello Júnior
Braz J Otorhinolaryngol. 2025;91:101500
Highlights

  • This consensus brings together the most up-to-date information on rhinitis.

  • Anamnesis is the key point in the suspected diagnosis and phenotype identification.

  • It is especially important to recognize comorbidities.

  • One aspect that impacts adequate treatment is low patient compliance.

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Brazilian Society of Otology task force – cochlear implant &#¿; recommendations based on strength of evidence
Robinson Koji Tsuji, Rogério Hamerschmidt, Joel Lavinsky, Felippe Felix, Vagner Antonio Rodrigues Silva
Braz J Otorhinolaryngol. 2025;91:101512
Highlights

  • Hearing preservation in Cochlear Implant (CI) surgery should be encouraged.

  • Even for patients with auditory nerve mutations, CI can still be recommended.

  • Despite gene therapy in preliminary studies with OTOF gene, CI is still indicated.

  • Patients with surgical wound infection should be evaluated and treated as quickly.

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Brazilian Society of Otology task force – single sided deafness – recommendations based on strength of evidence
Robinson Koji Tsuji, Rogério Hamerschmidt, Joel Lavinsky, Felippe Felix, Vagner Antonio Rodrigues Silva
Braz J Otorhinolaryngol. 2025;91:101514
Highlights

  • CND and cCMV should be prioritized in the investigation of congenital SSD.

  • CI is not recommended in children with SSD due to CND.

  • CI is the most effective treatment for restoring hearing in SSD.

  • Insufficient evidence to determine auditory deprivation duration for CI in SSD.

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Postoperative adjuvant chemoradiotherapy versus postoperative adjuvant radiotherapy for head and neck squamous cell carcinoma with adverse pathology: a systematic review and meta-analysis
Gabriela Garcia Korczaguin, Gilberto Vaz Teixeira, Ashok Shaha
Braz J Otorhinolaryngol. 2025;91:101516
Highlights

  • Overall and disease-free survival are greater in the adjuvant chemoradiation group.

  • Head and neck cancer recurrence is lower in the adjuvant chemoradiation group.

  • The rate of metastasis does not significantly differ between the adjuvant groups.

  • The rate of late toxicity does not significantly differ between the adjuvant groups.

  • The rate of acute skin toxicity is lower in the adjuvant chemoradiation group.

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Perineural invasion and laryngeal squamous cell carcinoma: a systematic review
Debora Modelli Vianna Ocampo Quintana, Rogerio Aparecido Dedivitis, Luiz Paulo Kowalski
Braz J Otorhinolaryngol. 2025;91:101519
Highlights

  • IPN is an independent factor for increased mortality in laryngeal cancer.

  • Meta-analysis concludes that IPN is causal factor for reduced survival and increased relapse.

  • Meta-analysis indicates need for standardization of definition and the study of IPN in future articles.

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Effectiveness of hypertonic saline irrigation following functional endoscopic sinus surgery: a systematic review and meta-analysis
Adriano Damasceno Lima, Rodolfo Baptista Giffoni, Julieta Arguelles-Hernandez, Gabriele Santos, Victor L.J.C. Sena, Ricardo S. Aguiar, Marcelo L.S. Cruz, Maria E.P. Dalmaschio, Marcio Nakanishi
Braz J Otorhinolaryngol. 2025;91:101517
Highlights

  • Review: hypertonic saline nasal irrigation after sinus surgery.

  • Chronic rhinosinusitis: frequent inflammatory disease, may need surgery.

  • Saline nasal irrigation: crucial post-surgery care for healing.

  • Study: hypertonic versus isotonic saline for nasal irrigation post-surgery.

  • Meta-analysis: best saline concentration for care after sinus surgery.

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Case reports
Immune reconstitution inflammatory syndrome mediated maxillary mucocele: a rare presentation
Vishwanath Gowda, Elsa Babu, Rajesh Radhakrishna Havaldar, Shilpa Mallapur
Braz J Otorhinolaryngol. 2025;91:101495
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A case of extranasopharyngeal angiofibroma arising from nasal dorsum
Tae-Gyun Kim, Chang-Ho Whangbo, Mi Kyung Ye, Seung-Heon Shin
Braz J Otorhinolaryngol. 2025;91:101508
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Enlarged vestibular aqueduct with bilateral sensorineural hearing loss following cranial trauma: a case report
Alexandre Camilotti Gasperin, Bruna Timm Monteiro, Ellen Paula Schetz Zawierucha, Enrico Guido Oliveira Minniti, Matheus Roberto Schetz Alves, Pedro Henrique Vicari Passos
Braz J Otorhinolaryngol. 2025;91:101518
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Brazilian Journal of Otorhinolaryngology (English Edition)
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Articles submitted as of May 1, 2022, which are accepted for publication will be subject to a fee (Article Publishing Charge, APC) payment by the author or research funder to cover the costs associated with publication. By submitting the manuscript to this journal, the authors agree to these terms. All manuscripts must be submitted in English.. Os artigos submetidos a partir de 1º de maio de 2022, que forem aceitos para publicação estarão sujeitos a uma taxa (Article Publishing Charge, APC) a ser paga pelo autor para cobrir os custos associados à publicação. Ao submeterem o manuscrito a esta revista, os autores concordam com esses termos. Todos os manuscritos devem ser submetidos em inglês.