Journal Information
Issue
portada-S1808869425X00021Vol. 91. Issue 3. (In progress)
(May - June 2025)
This issue is in progress but contains articles that are final and fully citable.
Editorials
The pitfalls of positional dizziness: Not everything is crystal
Lucas Resende Lucinda Mangia, Raquel Mezzalira, Roseli Saraiva Moreira Bittar
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Original articles
Who’s afraid of Dura Mater?
Mario Emilio Zernotti, Javier Gavilán
Highlights

  • New names for Bonebridge positioning.

  • Avoid “retrosigmoid” and “middle fossa”.

  • Names include easy to remember acronyms of anatomic location.

  • STELLA, PIA & MARA.

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Identification of TMEM71 as a hub NLRP3-related gene suppressing malignant behavior in nasopharyngeal carcinoma via the NLRP3/Caspase-1/GSDMD signaling pathway
Dan Liu, Yuanzhou Liu, Ruixiang Cen
Highlights

  • Identified 26 key NRGs in NPC tumors.

  • TMEM71 linked to immune cell infiltration in NPC.

  • TMEM71 as a prognostic factor in NPC.

  • TMEM71 inhibits NPC malignant behavior via NLRP3/caspase-1/GSDMD pathway.

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Patients’ satisfaction and efficacy of modern conventional hearing aids: A comprehensive analysis of the self-reported user experiences in adult people
Daniele Portelli, Cosimo Galletti, Sabrina Loteta, Leonard Freni, Francesco Ciodaro, Angela Alibrandi, Giuseppe Alberti
Highlights

  • Hearing loss impacts communication and mental health across ages.

  • Stigma and aesthetics limit hearing aid use, notably among youth.

  • Untreated hearing loss causes isolation and depression.

  • Smaller, discreet hearing aids enhance user satisfaction.

  • Research should diversify to explore adoption factors fully.

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Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy
Mengyi Liu, Lue Zhang, Quanming Zhang, Nan Zeng, Shuo Li, Shuyue Guo, Yaqin Zhao, Mingxing Tang, Qiong Yang
Highlights

  • Large mastoid cavity after CWD mastoidectomy should be obliterated properly.

  • HA particles used for cavity obliteration should be properly covered.

  • CGF promotes complete epithelialization of the mastoid cavity.

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The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments
Yani Liu, Yanyan He, Shizhen Lei
Highlights

  • Cuproptosis was the most enriched type of Programmed Cell Death (PCD) processes in THCA.

  • Cuproptosis was associated with tumor malignancy of THCA.

  • A cuproptosis-related gene, CDKN2A, was upregulated in THCA sample.

  • CDKN2A was associated with poor prognosis and TME in THCA.

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Clinical study of the diagnosis of thyroid tumours using Raman spectroscopy
Qingjian He, Lianjin Qin, Yongqiang Yao, WenJuan Wang
Highlights

  • RS provides unique spectral characteristics.

  • RS diagnosis can be completed in a short time.

  • Non-invasiveness, accuracy, rapidity, objectivity and cost-effectiveness.

  • RS not cause any damage to tumour specimens, more objective and rapid.

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A novel cochlear implant assessment tool: Audiometric and speech recognition analysis
Fernanda Ferreira Caldas, Byaka Cagnacci Buzo, Bruno Sanches Masiero, Alice Andrade Takeuti, Carolina Costa Cardoso, Fabiane de Castro Vaz, Fayez Bahmad
Highlights

  • Facilitate the cochlear implant programming for both patients and professionals.

  • New possibility of evaluation in tests of pure tone and speech recognition.

  • Possibility of expanding the use of new evaluation methodologies.

  • Improve the viability of clinical care.

  • Expand this care model in centers that do not have a sound booth.

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Sensorineural hearing loss and CT abnormalities in otosclerosis: Insights from otopathological specimens
Rafael da Costa Monsanto, Cassiano Mangini Dias Malpaga, Hélio Kiitiro Yamashita, Flávia Barros Suzuki, Norma de Oliveira Penido
Highlights

  • Otosclerosis is linked to a high rate of Sensorineural Hearing Loss (SNHL).

  • The prevalence of SNHL we found is higher than earlier reported.

  • Many otosclerosis cases with sensorineural loss may go undiagnosed, hindering care.

  • Our study offers insights to support further research in diagnosis and treatment.

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Docetaxel and cisplatin induction chemotherapy with or without fluorouracil in locoregionally advanced head and neck squamous cell carcinoma: A real-world data study
Matheus Yung Perin, Vivian Naomi Horita, Daniel Naves Araújo Teixeira, Joyce Gruenwaldt, Eduardo Baldon Pereira, Carlos Takahiro Chone, Gustavo Jacob Lourenço, Ligia Traldi Macedo, Carmen Silvia Passos Lima
Highlights

  • Induction therapy with TPF or TP has been indicated for advanced HNSCC patients.

  • TPF is more toxic and requires infusion device or in-hospital administration of 5-FU.

  • We analyzed the outcomes of advanced HNSCC patients treated with TPF or TP.

  • ICT regimens did not alter patients’ toxicity, response rate and survival.

  • TP is a good treatment option for advanced HNSCC in socioeconomically limited settings.

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Advanced age is not a predictor for cochlear implantation outcomes in adults with moderate to profound sensorineural hearing loss
Dayse Távora-Vieira, Andre Wedekind, Aanand Acharya, Jafri Kuthubutheen, Marcus Voola, Vinicius Cavalheri, Peter Friedland
Highlights

  • A CI improves speech understanding and subjective hearing results within the first 12-months.

  • Outcomes were not dependant on age at implantation.

  • Cochlear implants should be offered to all eligible patients.

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Effectiveness of bony batten grafting for correction of caudal septal deviations
Nátalie Emy Yvamoto, Marco Antonio dos Anjos Corvo, Rodolfo Alexander Scalia, Eduardo Landini Lutaif Dolci
Highlights

  • Use of septal bone graft intraoperatively to correct anterior septal deviations.

  • Reduction in the Nose Scale in patients who utilized Bone Septal Batten.

  • The septal bone graft usually discarded in surgery can be used in rhinoseptoplasty.

  • Bone grafting has low resorption rates and complications related to its use.

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Transcriptomic analysis reveals the function of m6A regulators in aged cochlea
Yanbing Lai, Bo Su, Xiaodi Wang, Chenghui Zeng, Hanqi Chu, Liangqiang Zhou, Dan Bing
Highlights

  • ALKBH5 and YTHDC1 are potential useful diagnostic markers for cochlear aging.

  • ALKBH5 and YTHDC1 are highly associated with immune pathways.

  • ALKBH5 and YTHDC1 are highly associated with immune cell infiltrate.

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Review articles
Cochlear implantation and cognitive function in the older adult population: current state of the art and future perspectives
Tinne Vandenbroeke, Ellen Andries, Marc J.W. Lammers, Anouk Hofkens-Van den Brandt, Griet Mertens, Vincent Van Rompaey
Highlights

  • Use of cochlear implants can attenuate cognitive decline in adults with hearing loss.

  • The cognitive test should be adapted for individuals with hearing loss.

  • Evoked response potentials might serve as an objective marker for cognition.

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Application of an active middle ear implant in congenital middle ear malformations: A contemporary review
Vagner Antonio Rodrigues da Silva, Henrique Furlan Pauna, Guilherme Correa Guimarães, Joel Lavinsky, Thomas E. Linder, Arthur Menino Castilho
Highlights

  • External ear malformations frequently lead to conductive hearing loss.

  • The Jahrsdoerfer score is used to qualify patients for corrective surgery.

  • Patients presented improvement of bone and air-conduction thresholds.

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Cochlear implantation in vestibular schwannoma: A game changer? A narrative review
Luis Lassaletta, Miryam Calvino, Isabel Sánchez-Cuadrado, José Manuel Morales-Puebla, Javier Gavilán
Highlights

  • Cochlear implantation is a solution for some patients with vestibular schwannoma.

  • Audiological outcomes are variable, but worse than conventional CI candidates.

  • Cochlear implantation can be performed in operated, observed or irradiated cases.

  • The Auditory Nerve Test System is a useful intraoperative tool.

  • A positive wave V elicited with the ANTS strongly predicts at least sound detection.

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Audiological findings in Brown Vialetto-Van-Laere Syndrome: A scoping review
Débora de Oliveira Rolim, Leticia Cristina Vicente, Hugo Amilton Santos de Carvalho, Rebeca Lorrane Santana Santos, Rivadávio Fernandes Batista de Amorim, Fayez Bahmad
Highlights

  • BVVL Syndrome is a rare alteration in the Riboflavin transporter gene.

  • Few studies describe the details of hearing loss in the syndrome.

  • The main finding was sensorineural hearing loss.

  • Objective tests were integrated into the audiological diagnosis process.

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Quality-of-life assessment instruments for patients with vestibular schwannoma: A systematic review
Katarzyna Bieńkowska, Barbara Kostecka, Andrzej Kokoszka
Highlights

  • Simultaneously use disease specific and generic QoL tools in VS patients.

  • Use the SF-36 as a generic tool and PANQOL as a disease-specific tool in VS studies.

  • Including medical data, questionnaires scores referring to VS to assess HRQOL.

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Case reports
Unilateral conductive hearing loss due to hydrocystoma in the external auditory canal: A rare case report
Francisco Campelo da Fonseca Neto, Renan Vieira de Brito, Eder Barbosa Muranaka, Arthur Menino Castilho
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Brazilian Journal of Otorhinolaryngology (English Edition)
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