Journal Information
Issue
portada-S1808869425X00033Vol. 91. Issue 4. (In progress)
(July - August 2025)
This issue is in progress but contains articles that are final and fully citable.
Original articles
Analysis of the frontal recess pneumatization pattern in patients with chronic frontal sinusopathy
Krystal Calmeto Negri, Rogério Hamerschmidt, Cassio Iwamoto, Carolina Rodrigues Laranjeira Vilar
Highlights

  • The supra-Agger frontal and supra bulla frontal cells predispose sinusopathy.

  • Supra bulla frontal cells are independent factors for the outcome.

  • Preoperative tomographic analysis provides greater safety to the surgery.

  • Tomographic analysis allows anatomical understanding of the recess and frontal sinus.

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Efficacy of the adjunctive use of photobiomodulation therapy in olfactory disorders in post-COVID-19 patients: A randomized controlled trial
Patricia Costa Oliveira, Luisa Oliveira Correia, Natalia Medeiros Dias Lopes, Gabriel Rodrigues Suassuna, Richard L. Doty, Fabio de Rezende Pinna, Richard Louis Voegels, Marco Aurelio Fornazieri
Highlights

  • PBMT with steroids and training improved post-COVID olfaction, especially infrared.

  • Infrared had a 68% response rate, surpassing red light (43.5%) and control (26.1%).

  • PBMT with steroids and olfactory training was safe for treating smell disorders.

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Longitudinal study of hearing preservation and electrocochleography after cochlear implantation in adults
Marianne Schleich, John J. Galvin, Fabrice Micaletti, David Bakhos
Highlights

  • Residual hearing significantly deteriorates after cochlear implantation.

  • 23.5% of the patients lose all residual hearing 1-year after cochlear implantation.

  • Preoperative thresholds are good predictors of postoperative outcomes.

  • ECOG correlates with postoperative audiometric thresholds in the short term.

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Definitive treatment in squamous cell carcinoma of head and neck: A retrospective analysis of chemoradiotherapy in a university hospital setting
Hádila Silva Veras Sousa, Vivian Naomi Horita, Davi Magalhães Leite Novaes, Matheus Yung Perin, Daniel Naves Araújo Teixeira, Joyce Gruenwaldt, Eduardo Baldon Pereira, Carlos Takahiro Chone, ... Carmen Silvia Passos Lima
Highlights

  • RT plus CP or Carbo has been used as definitive treatment for advanced SCCHN.

  • Efficacy of protocols in SCCHN patients of developing countries are unknown.

  • We analyzed outcomes of advanced SCCHN patients treated with both protocols.

  • Patients treated with RT plus Carbo had double chance of relapse and death.

  • CP was the best agent for advanced SCCHN in economically limited settings.

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Prolonged noise exposure-induced auditory threshold shifts in wistar rats: Proposal of an experimental exposure protocol based on noise dose
Ana Carolina Odorizzi Zica, Gabriela Ribeiro Novanta, Maria Luiza Queiroz Sampaio, Rafael Rocha de Andrade, Lucieny Silva Martins Serra, André Luiz Lopes Sampaio
Highlights

  • Occupational noise being the main cause of sensorineural hearing loss in adults.

  • Short-term noise exposures that possibly generated temporary damage.

  • Intensity and time are determining factors in exposure to noise.

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Clinical and audiological profile of patients with sudden sensorineural hearing loss after exposure to recreational noise
Lara Freire Bezerril Soares, Breno Lima de Almeida, Igor Ataíde Silva Teixeira, Maria Luisa Frechiani Lara Maciel, Jorge Vinícius Leocádio Monteiro, Luanna Miranda Martins, Marina Cançado Passarelli Scott, Norma de Oliveira Penido
Highlights

  • Recreational acoustic trauma is a growing public health concern in young people.

  • Profiles of young adults with sudden hearing loss after noise exposure are described.

  • Noise exposure included music events and parties for 3–5 h near sound sources.

  • Recreational drug use is common and harms hearing health, alongside noise exposure.

  • Significant auditory sequelae may occur due to variable rates of hearing recovery.

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Towards an adult hearing screening procedure
Marc Jan-Willem Lammers, Chris Raine, Griet Mertens, Vincent van Rompaey, Rudolf Hagen, Anja Kurz, Piotr Henryk Skarzynski, Artur Lorens, ... Ilona Anderson
Highlights

  • The adult HEARRING screening protocol is a consensus protocol.

  • It is developed for easy implementation in primary care clinics.

  • The protocol is based on the World Health Organization recommendations.

  • It can assist clinicians in initiating effective hearing screening programs.

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Diagnosis of a patient with severe sensorineural hearing loss as the initial symptom caused by novel compound heterozygous variant in SLC19A2 gene
Yanan Shi, Junyang Li, Xiaoqin Chen, Niu Li, Sijie Yang, Youjin Li, Min Zhou
Highlights

  • Identified novel compound heterozygous variants in SLC19A2 causing TRMA syndrome.

  • Severe sensorineural hearing loss was the initial symptom in a TRMA syndrome case.

  • cDNA analysis confirmed exon 3 skipping and frameshift mutation in SLC19A2.

  • TRMA syndrome should be considered in patients with hearing loss and glucose issues.

  • Findings expand the pathogenic variant spectrum of SLC19A2 in TRMA syndrome.

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Identification of key hub genes and potential therapeutic drugs for nasopharyngeal carcinoma: Insights into molecular mechanisms and treatment strategies
Haiyan Quan, Hongguo Yin, Zhen Wang, Yuan Lv, Qiong Sun, Ting Yin
Highlights

  • Eight key hub genes identified as drivers of NPC progression.

  • Drug screening identified calcitriol as a potent inhibitor of NPC proliferation.

  • Provides novel molecular insights and potential therapeutic strategies for NPC.

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Serum metabolites and risk of sudden sensorineural hearing loss: A Mendelian randomization study
Wenhui Yuan, Yong Liu, Chao Liu, Yuanzheng Qiu
Highlights

  • Cholesterol, citrate, myristoleate (14:1n5) and tryptophan betaine may cause SSNHL.

  • Stearate (18:0), pantothenate and glycerol 2-phosphate may be protective for SSNHL.

  • Bonferroni correction had the ability to eliminate these above correlations.

  • The above findings can be instructive for future research on SSNHL.

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Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis
Fan Jiang, Junhao Tu, Wenqi Luo, Yizhen Jia, Qing Luo, Jing Ye
Highlights

  • Analyzed chronic rhinosinusitis and metabolites using Mendelian randomization.

  • Tyrosine and creatinine are the main pathogenic factors.

  • 24 circulating metabolites are protective factors.

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Causal relationship and potential pathogenic mechanisms between rosacea with pharyngeal and laryngeal cancer
Zexin Zhu, Xiaoxue Wang
Highlights

  • A variety of MR analysis methods are used.

  • Causal link between Rosacea and PLC (Pharyngeal and Laryngeal Cancer).

  • No causal relationship between Rosacea and other cancer.

  • Sensitivity analysis confirm the robustness and reliability of the findings.

  • Explored the molecular pathogenic mechanism between Rosecea and PLC.

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External auditory canal cholesteatoma: 20 years of experience
Federico Herranz, Julián Agustín Simkin, Federico Di Lella, Gabriela Perez Raffo
Highlights

  • Clinical and surgical approaches used for managing external auditory canal cholesteatoma.

  • Non-surgical treatment effectively controlled 53.84% of external canal cholesteatomas.

  • Advanced cases required canaloplasty, reconstruction, or mastoidectomy.

  • 95.83% of surgically treated patients showed no recurrence after follow-up.

  • Stage II was most common, accounting for 63.5% of cases.

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Radiation-free automatic planning for cochlear implantation: Comparing cochlear duct lengths between CT and MRI
Asma Alahmadi, Fida Almuhawas, Afrah Alshalan, Ibrahim Shami, Eman Hajr, Yassin Abdelsamad, Abdulrahman Alsanosi
Highlights

  • Radiation Free CI Planning.

  • Utilizing auto-MRI planning for CI surgery facilitates the process and minimize risk.

  • Automated cochlear measurement using MRI is comparable to manual CT & MRI assessment.

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Causal relationship between gut microbiota and laryngeal cancer: a mendelian randomization analysis
Kaiyan Yi, Yu Huang, Yun Jiang, Lingling Zhou
Highlights

  • This study establishes a link between gut microbiota and laryngeal cancer risk.

  • Clostridiaceae1 and Turicibacter can reduce the risk of laryngeal cancer.

  • Mollicutes RF9, Euryarchaeota and Cyanobacteria can improve laryngeal cancer’s risk.

  • Targeting gut microbiota can offer strategies for laryngeal cancer’s treatment.

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Efficacy analysis of non-invasive correction for congenital cryptotia with auricular cartilage deformities
Zhiying Zhou, Jiahua Shen, Lexi Lin, Wenxin Chen, Yong Fu
Highlights

  • Non-invasive correction effective for congenital cryptotia with cartilage deformities.

  • Shorter correction time for infants under 3-months with high cartilage deformity rate.

  • Non-invasive correction considered for infants over 3-months, longer duration needed.

  • Correction still effective for infants over 6-months, lower cartilage deformity rate.

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Review articles
Isotretinoin use in rhinoplasty patients
Jholbert Cardoso Santana, Hugo Valter Ramos Lisboa, Leandro Azevedo de Camargo, Ricardo Araújo Meira Almeida, Lourival Mendes Bueno
Highlights

  • It is possible concluding that isotretinoin has potential aesthetic benefits.

  • Studies have pointed towards improved skin appearance and nasal tip definition.

  • However, these benefits may be more visible in the initial postoperative period.

  • There are no protocols in the literature regarding dosage and duration of treatment.

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Long-term efficacy and safety of different biologics in treatment of chronic rhinosinusitis with nasal polyps: A network meta-analysis
Han Chen, Lin Wang, Jisheng Zhang, Xudong Yan, Longgang Yu, Yan Jiang
Highlights

  • Dupilumab tops for CRSwNP in network meta-analysis, reducing NPS and symptoms.

  • Biologics exhibit comparable long-term safety to placebo.

  • Personalized biologic choice crucial in CRSwNP; prolonged studies needed.

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Case reports
Fluctuating hearing loss associated with a novel heterozygous variant in the TNC gene related to nonsyndromic hearing loss
Mariana Carolina Castellanos-Acevedo, Juan C. Ospina-García, Carlos Alberto Restrepo-Chamorro
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Brazilian Journal of Otorhinolaryngology (English Edition)
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Articles submitted as of May 1, 2022, which are accepted for publication will be subject to a fee (Article Publishing Charge, APC) payment by the author or research funder to cover the costs associated with publication. By submitting the manuscript to this journal, the authors agree to these terms. All manuscripts must be submitted in English.. Os artigos submetidos a partir de 1º de maio de 2022, que forem aceitos para publicação estarão sujeitos a uma taxa (Article Publishing Charge, APC) a ser paga pelo autor para cobrir os custos associados à publicação. Ao submeterem o manuscrito a esta revista, os autores concordam com esses termos. Todos os manuscritos devem ser submetidos em inglês.