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Cover Vol. 91. Issue 5.Vol. 91. Issue 5.
(September - October 2025)
Editorials
What can be done to reduce surgical waiting time for pediatric ent in public health care in Brazil?
Reginaldo Raimundo Fujita, Shirley Shizue Nagata Pignatari, Vitor Guo Chen, Paula Angelica Lorenzon, Luciano Rodrigues Neves, Gabriela Ricci Lima Luz Matsumoto, Manoel de Nobrega, Ektor Tsuneo Onishi, ... Jaquelina Ota Araki
Braz J Otorhinolaryngol. 2025;91:
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Original articles
First bite syndrome following surgical management of primary jugular foramen lesion: Clinical experience and review of the literature
Xinrui Xu, Mengye Ma, Qianru Wu, Xunbei Shi, Feitian Li, Chunfu Dai
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • First bite syndrome may occur after resection of primary jugular foramen lesions.

  • Symptoms of first bite syndrome is mild in these patients postoperatively.

  • The rationale could be push of the sympathetic plexus along the internal carotid artery.

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The effect of blood glucose and lipid risk factors on idiopathic sudden sensorineural hearing loss: A two-sample Mendelian randomization study
Bang-yu Deng, Yun-xia Zhao, Ji-sheng Liu
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • TG was a potential risk factor for SHL.

  • Increased TG levels significantly raising the risk of SHL.

  • Blood glucose and other lipid risk factors did not increase ISSHL risk.

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Morphometric evaluation of cerebral and cerebellar structures in long-term unilateral sensorineural hearing loss
Gözde Orhan Kubat, Özkan Özen, Emre Çolak
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Unresolved issues remain in brain, cerebellum morphometry in USNHL patients.

  • FO, STG, and lobule IX show differences between patients and control groups.

  • Neurological and psychiatric disorders from damage here need hearing evaluation.

  • Patients with no known causes should be checked for hearing-related changes.

  • Volbrain offers fast, accurate data with systematic error correction.

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Predictive factors for outcomes of sialoendoscopy
Hannah Damasceno Barreto, Jose Higino Steck, Samuel Serpa Steck, Diogo Silva de Carvalho, Carlos Takahiro Chone
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Chronic sialoadenitis is mainly treated with surgical procedures.

  • Sialoadenectomies may result in aesthetic defects and complications.

  • Sialoendoscopy is an effective treatment for major salivary gland duct diseases.

  • Sialoendoscopy boasts minimal complications and high success rates.

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Disulfidptosis ‒ related lncRNAs are biomarkers of prognosis and immune response in Head and Neck Squamous Cell Carcinoma
Ruilin Wang, Qi Zhang, Yuxiu Ma, Xuelin Liu, Tian Lan, Hongling Li
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Disulfidptosis-related lncRNAs can predict the prognosis of HNSCC patients.

  • Disulfidptosis-related lncRNAs are associated with tumor mutational burden in HNSCC.

  • Disulfidptosis-related lncRNAs are closely related to immune responses in HNSCC.

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Rhinosinusitis: Evidence and experience – 2024
Fabrizio Ricci Romano, Wilma Terezinha Anselmo-Lima, Eduardo Macoto Kosugi, Eulalia Sakano, Fabiana Cardoso Pereira Valera, Marcus Lessa, Renato Roithmann, Shirley Pignatari, ... Otávio Bejzman Piltcher
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Prolonged Acute Viral Rhinosinusitis is a cold lasting more than 7–10 days, with slow and progressive improvement, reinforcing its typically viral origin.

  • Antibiotics should be used only in severe, unequivocally diagnosed ABRS. For moderated cases, the “watchful waiting/delayed prescription”, is recommended.

  • Suspicion of orbital complication should be investigated with contrast CT and hospitalization under intravenous antibiotic therapy. Consider surgery.

  • Surgery plays a very important role in the management of CRS. Either curative or providing control of the disease combined with medical treatment.

  • Biologics are a good treatment option for some patients with severe CRSwNP refractory to standard treatment.

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Can the co-localization of CD8+, PD-1, PD-L1 AND PD-L2 patterns provide guidance in clinical outcomes of patients with head and neck cutaneous squamous cell carcinoma?
Gustavo Nunes Bento, Andre Bandiera de Oliveira Santos, Leandro Luongo Matos, William C. Faquin, Sara I. Pai, Claudio Roberto Cernea
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • The co-localization of PD-1/PD-L1 could be a promising tool for prognostic evaluation.

  • The first study to assess co-localization of CD8, PD1, PDL1, PDL2 in cSCC.

  • Notable presence of CD8+T-cell infiltration in cSCC, co-localizing with PD-L1/L2.

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A novel and effective surgical procedure for posterior nasal neurectomy in patients with allergic rhinitis
Weini Hu, Qiang Zuo, Dawei Wu, Yu Song
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Minimally invasive procedure of posterior nasal neurectomy.

  • Accurate and cost-effective way to locate the sphenopalatine foramen.

  • Quicker postoperative wound recovery and fewer surgical complications.

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Comparative analysis between the gold standard titration method and a mathematical formula to predict CPAP pressure
Cíntia Felicio Adriano Rosa, Adriane Iurck Zonato, Ordival Augusto Rosa
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • The high demand leads to the need to explore predictive formulas for CPAP pressure.

  • Baseline AHI, BMI, and NC predict higher CPAP pressure during titration.

  • Formula could enhance home treatment defining min‒max pressures with APAP.

  • Formula underestimated CPAP pressure; reassess if symptoms persist or treatment fails.

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Cross-cultural adaptation and validation of the theory of Planned Behavior-Hearing Help Seeking: A methodological study
Yuxuan He, Menghui Deng, Wei Li, Jia Liu, Xiaomei Chen, Yanni Yang
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • The TPB-HHS is suitable for assessing help-seeking behavior in the community.

  • TPB-HHS was cross-culturally adapted to the Chinese language in China.

  • The Chinese version TPB-HHS scale items and structure are similar.

  • TPB-HHS can be used for assessment, follow-up, and intervention.

  • TPB-HHS translates and adapts well to Chinese.

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Voice symptoms, dysphagia risk, quality of life, and mental health in total laryngectomized patients: a self-perception study
João Vitor Barbosa Pereira, Vaneli Colombo Rossi, Carlos Takahiro Chone, Ana Carolina Constantini
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Total laryngectomy patients self-report vocal symptoms.

  • Risk for dysphagia is a determinant of quality of life and mental health.

  • The risk for dysphagia is related to greater functional impairment.

  • Subjects in psychological distress presented greater functional and health impairment.

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CeRNA network reveals potential diagnostic biomarkers or immunotherapy targets for Hypopharyngeal squamous cell carcinoma
Xi Yang, Chun Feng, Donghui Jiang, Xin Xu, Yingying Zhang, Jin Wang, Xiaoguang He
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Screened biomarkers related to the HSCC.

  • NRG1, CCNG2, CHSY1 with diagnostic value were recognized.

  • ceRNA network was established, new insight of HSCC.

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Development and validation of prognostic prediction model for submandibular gland cancer based on the SEER database
Junkun He, Feng Zhao, Jiangmiao Li, Qiyun Li, Fangyu Wei, Jiping Su
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Prognosis of submandibular gland carcinoma remains challenging to predict.

  • Lasso regression selected key prognostic factors.

  • Cox regression model established for prognostic prediction.

  • The model demonstrated accuracy with c-indexes in training and validation sets.

  • Decision curve analysis confirmed the model’s clinical utility.

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Metabolic biomarkers mediate allergic rhinitis via circulating inflammatory proteins: Evidence from a Mendelian randomization study
Xiang Cao, Boyang Zhang, Wei Wang, Zijiao Xu, Zhixin Jiang
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Used genetic data to clarify causes of AR, reducing confounding factors.

  • Genetic evidence supports IL-6, CCL19, and DNER as risk factors for AR.

  • IL-10 exhibits a protective effect against AR.

  • Key MBs (AMP-to-urate ratio, lactate, N-acetylputrescine) mediate AR risk.

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Association of tinnitus with obstructive sleep apnea and rapid eye movement-related obstructive sleep apnea in similar hearing threshold groups
Sun Choi, Seok Hyun Park, Su Yeon Kim, Su Kyoung Park, Sang Chul Park, Jiwon Chang
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • OSA patients with tinnitus had better sleep efficiency than those without tinnitus.

  • OSA patients with tinnitus took more sleep medications than those without tinnitus.

  • Tinnitus in OSA patients was more related to subjective than objective parameters.

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Trends and future directions in chronic rhinosinusitis with nasal polyps: A bibliometric analysis
Yeming Zhong, Xuan Wei, Caiyun Zou, Bo Qian, Hongbo Ji, Jinhe Guo, Zigang Che
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • CRSwNP significantly impairs patients' quality of life.

  • Study analyzes publications from 2004 to 2024.

  • United States leads in publication volume.

  • Key themes: inflammation, biologics, and surgery.

  • Future focus on safety and precision medicine.

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Aberrant expression of Bcl2L12 as a potential biomarker for predicting recurrence in nasal polyp
Ping Zhang, Fengjun Wang
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • CRSwNP with eosinophilic infiltration has a high rate of recurrence.

  • Tissue Bcl2L12 levels were increased in the CRSwNP group.

  • Tissue Bcl2L12 levels might predict recurrence of CRSwNP.

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Bilateral middle ear cholesteatoma in children: A single-center retrospective study
Xiaoxu Wang, Lining Guo, Enxia Tian, Min Chen, Wei Liu, Xin Ni, Jie Zhang
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • The incidence of cleft palate malformation in BMEC is high.

  • Staging bilateral surgery is preferred and surgery on the worse side first.

  • Simultaneous bilateral surgery in children should be carefully considered.

  • Postoperative hearing showed no significant difference between CC and AC in BMEC.

  • BMEC has a high recurrence rate after operation and require a long-term follow-up.

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Review articles
Outcomes in patients with head and neck squamous cell carcinoma with exclusively surgical resection
Daniel Naves Araujo Teixeira, Fabio Lau, Vanessa Carvalho de Oliveira, Eduardo Vieira Couto, Thomas Peter Maahs, Carmen Silvia Passos Lima, Carlos Takahiro Chone
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • The overall survival at 5-years was estimated at 74.7%.

  • The disease-free survival at 5-years was estimated at 69.3%.

  • Active smoking patients had a 9.4 times higher risk of death.

  • Active smoking patients had a 9.7 times higher risk of recurrence.

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Quality of life in children with unilateral hearing loss undergoing cochlear implantation: A systematic review and meta-analysis
Paola Piva de Freitas, Rafael Freire de Castro, Ana Paula de Morais e Oliveira, Carlos Takahiro Chone, Arthur Menino Castilho
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Children with SSD experience many developmental challenges and poor quality of life.

  • CI has previously been shown to improve hearing, although QoL outcomes remain underreported.

  • This review shows improvement in QoL for parents and children and good adherence to CI.

  • Similar QoL improvement and duration of use for congenital and post-lingual groups.

  • Factors associated with discontinuation need further investigation.

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Brazilian Journal of Otorhinolaryngology (English Edition)
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Articles submitted as of May 1, 2022, which are accepted for publication will be subject to a fee (Article Publishing Charge, APC) payment by the author or research funder to cover the costs associated with publication. By submitting the manuscript to this journal, the authors agree to these terms. All manuscripts must be submitted in English.. Os artigos submetidos a partir de 1º de maio de 2022, que forem aceitos para publicação estarão sujeitos a uma taxa (Article Publishing Charge, APC) a ser paga pelo autor para cobrir os custos associados à publicação. Ao submeterem o manuscrito a esta revista, os autores concordam com esses termos. Todos os manuscritos devem ser submetidos em inglês.