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Cover Vol. 91. Issue 6.Vol. 91. Issue 6.
(November - December 2025)
Editorials
The emerging role of platelet-rich plasma subepithelial infusion for vocal fold scar, sulcus, and atrophy
Gustavo Polacow Korn, Michal M. Johns
Braz J Otorhinolaryngol. 2025;91:
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Original articles
Expression of ApoE and Spp1 in the cochlea and auditory cortex of age-related hearing loss mice
Yingxue Yuan, Junhong Zhang, Jingyi Zhao, Xiru Zhang, Zhixin Cao
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Differential expression proteins in presbycusis mice identified via proteomics.

  • ApoE and Spp1 upregulated in the cochlea and auditory cortex of presbycusis mice.

  • ApoE and Spp1 affect auditory neural transmission, contributing to presbycusis onset.

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Functional outcomes of otosclerosis surgery
Nadia Romdhane, Dorra Chiboub, Amal Nessib, Ameni Amri, Ines Hariga, Chiraz Chaouch Mbarek
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Better results with early Aubry stages (I and II).

  • Better functional outcomes with early Portmann stages.

  • Stapedectomy exposes to a higher risk of air bone gap reopening in long-term.

  • Better auditory results and less complications with calibrated platinotomy.

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Clinicopathological analysis of hyalinizing clear cell carcinoma in the head and neck
Xiaoli Zhao, Donglin Ma, Yahui Li, Dongmei Yang, Yingshi Piao
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Hyalinizing Clear Cell Carcinoma (HCCC) is a rare, low-grade malignant tumor.

  • HCCC is frequent misdiagnosis.

  • Combination of analytical techniques can be used to accurately diagnose HCCC.

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The effect of nigella sativa oil on healing in nasal septum perforations
Ahmet Koder, Onur Ersoy
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • NSO significantly enhances healing in Nasal Septum Perforations (NSP) in rats.

  • NSO increases collagen density and improves surface morphology, aiding structural repair.

  • Higher PCNA levels in the NSO group indicate enhanced cellular proliferation.

  • NSO's healing effects occur without altering VEGF levels.

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Assessment of depression in total laryngectomy patients
Kelen Fernanda Catarochi, Vaneli Colombo Rossi, Carlos Takahiro Chone
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Symptoms of depression are found in a large percentage of total laryngectomy.

  • Sleep patterns show significant changes in 63% of the cases interviewed.

  • Marital status, sex, age and therapies do not correlate with depression.

  • The longer the time after surgery, the lower the depression scale index.

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Cancer stem cell biomarkers in locally advanced head and neck squamous cell carcinoma
Miguel Caballero-Borrego, Juan J. Grau, Neus Basté, Paola C. Castillo, Cristina Teixido, Izaskun Valduvieco, Isabel Vilaseca
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Patients with carcinoma of the head and neck respond differently to treatment.

  • The presence of cancer stem cells may explain the tumor resistance to treatment.

  • Some cancer stem markers are CD44, HLA-I, pan-cytokeratin, and EGFR.

  • HLA-I and CD44 are prognostic factors for survival, but not pan-CK or EGFR.

  • Knowing the type of stem cells that integrate a cancer could help guide treatment.

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The agger nasi approach to the uncinate process: From top to bottom
Miguel Soares Tepedino, Luziana de Lima Ramalho, Leonardo Balsalobre, Andrea Santos Dumont Costa Curta, Debora de Carvalho Garcez, Rogerio Pezato
Braz J Otorhinolaryngol. 2025;91:
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Prevalence of decreased olfactory function in adults in a Brazilian population sample
Wilker Antunes Lira, Gilmar Felisberto Junior, Marco Aurélio Fornazieri, Wilma Terezinha Anselmo Lima, Ingrid Werner Picinini, Vanessa Ramos Pires Dinarte
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Older individuals with an 8% increased risk of developing loss of smell.

  • Low correlations between self-reported olfactory function and objective performance.

  • The sense of smell is often underestimated.

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Adenoid hypertrophy is directly associated with the severity of OSA in obese children: A pilot study
Victor Hugo da Costa Ferreira, Carolina Sponchiado Miura, Bruna de Alencar Custodio Lupoli, Denny Marcos Garcia, Bruno Carvalho Portes Lopes, Fernando Gustavo Stelzer, Fábio Lourenço Romano, Tabata Luna Garavazzo Tavares, ... Fabiana Cardoso Pereira Valera
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Adenoid hypertrophy is intrinsically related to OSA severity in obese children.

  • DISE should be ideally recommended for children without adenotonsillar hypertrophy.

  • The parameters in awake and DISE evaluations were equally related to OSA severity.

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Impact of prosthesis position on hearing outcomes in otosclerosis patients based on ultra-high-resolution CT
Chen Yang, Heyu Ding, Ting Zhang, Pengfei Zhao, Zhenchang Wang, Shusheng Gong, Jing Xie
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Comparison between mean pre- and post-operative ABG.

  • The relationship between prosthesis position and post-operative ABG.

  • The advantages of Ultra-High Resolution Computed Tomography (U-HRCT).

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Clinical outcomes of high-frequency electrocautery surgery and proton pump inhibitor therapy for refractory laryngeal contact granuloma
Zelong Wang, Xianbin Lan, Yuan Fang, Shaoping Peng, Riqun Jin, Dongming Deng, Zhiheng Song
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Local anesthesia electrocautery via laryngoscopy treats RLCG.

  • Combining with acid-suppressing therapy boosts efficacy.

  • This combination shortens disease course and is highly effective.

  • The procedure is simple, well-tolerated, and cost-effective.

  • It improves symptoms quickly without general anesthesia or intubation.

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Clinical predictors of survival in malignant peripheral nerve sheath tumors of the head and neck: A cox regression and nomogram study
Sun LiNa, Tu Jianfei, Tian Zhifeng, Wang Xinbin, Wu Hui
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Radiotherapy improves survival in cases with metastatic disease.

  • Surgery and radiotherapy are important in patients with tumors ≥6 cm.

  • Chemotherapy has limited efficacy in reducing the mortality of MPNST.

  • An effective survival prediction model for patients with head and neck MPNST.

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Accuracy of the ABFW ‒ Screening for speech disorders in early childhood
Marianna Momoe Nanakuma Matsumoto, Bruna Fernanda Alves da Silva, Maria Luiza Paulo de Oliveira Costa, Amanda Aparecida Carneiro, Daniela Regina Molini-Avejonas
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • 188 protocols were analyzed.

  • Balanced accuracy of 64.3% for all speech therapy hypotheses.

  • Sensitivity of 94.12% and specificity of 92.31% for the diagnostic hypothesis of AS.

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National trends in laryngectomy and the influence of hospital volume on short-term outcomes in Brazil: A 16-year cross-sectional analysis
Rafael Filipe Dal Ben Martins, Bruna Andressa Quirino, Leandro Luongo Matos, Marcelo Passos Teivelis, Nelson Wolosker, Ana Kober Nogueira Leite
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Significant reduction in total laryngectomies in Brazil over 16-years.

  • Very low-volume hospitals had significantly higher in-hospital mortality.

  • Centralization of laryngectomy services may improve surgical outcomes in Brazil.

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Estrogen-mediated TRPV5 modulates proliferation and apoptosis of rat cochlear hair cells via the PI3K/Akt pathway
Yao Zhou, Shouju Huang, Lijuan Zhao, Chengzhen Pan, Jianguo Wang, Shuxia Qian
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • BPPV, as a very common vestibular dysfunction, is more prevalent in elderly women.

  • TRPV5 is an important Ca2+ transporter mediated by estrogen in bone microenvironment.

  • Overexpression of TRPV5 promotes cochlear hair cell proliferation and apoptosis.

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One-year efficacy of Dupilumab in sense of smell, nasal polyp score and quality of life in CRSwNP patients: A real-world multicenter study in Brazil
Otávio Marana Mieli, Fabiana Cardoso Pereira Valera, Vanessa Ramos Pires Dinarte, Clara Mônica Figueiredo de Lima, Marcio Nakanishi, Maria Eduarda Trocoli Zanetti, Felipe Oliveira Pires, Denny Marcos Garcia, ... Wilma Terezinha Anselmo-Lima
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) impacting quality of life.

  • Patients with CRSwNP presents nasal obstruction and loss of sense of smell.

  • Real-world data show that dupilumab improved parameters in CRSwNP.

  • Nasal polyp score, smell function, and quality of life test showed improvement.

  • Results support the benefits of dupilumab in treating cases of CRSwNP in Brazil.

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Effects of fibroblasts-derived exosomal FAP in regulating EMT in epithelial cells from chronic rhinosinusitis
Li-Fang Shen, Zi-Ming Fu, Hai-Hong Chen
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • NPF released more FAP-enriched exosomes upon stimulation of IL-36γ.

  • The exosomes from NPF could be internalized by nasal epithelial cells.

  • NPF-derived FAP-containing exosomes could induce the EMT of epithelial cells.

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Competencies in Head and Neck Surgery teaching for medical internship. Position statement of Brazilian Head and Neck Surgery Society
Mario Augusto Ferrari de Castro, Rogerio Aparecido Dedivitis, Fatima Cristina Mendes de Matos, Marianne Yumi Nakai, Leandro Luongo de Matos, Marco Aurelio Vamondes Kulcsar, Flavio Carneiro Hojaij, Carlos Takahiro Chone, ... Giovana Meira Muller
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Competency-based education ensures that medical students achieve proficiency.

  • An expert panel consisted of 25 specialists participated in Delphi process.

  • 12 competencies were generated for medical students in Head and Neck Surgery.

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Review articles
Sequential flaps reconstruction in head and neck cancer: A systematic review
Yu Xiong, Zepeng Xu, Mailudan Ainiwaer, Zheng Jiang, Fei Chen
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Sequential flaps can be used as an effective method for head and neck reconstruction.

  • The survival rate of sequential flaps was 94.6%.

  • The anterolateral thigh flap is the mostly used sequential flap type.

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The Green Cochlea
Abdulrahman Hagr, Farid Alzhrani, Fida Almuhawas, Yassin Abdelsamad, Medhat Yousef, Asma Alahmadi, Christiana Kyvelidou, Ilona Anderson
Braz J Otorhinolaryngol. 2025;91:
Highlights

  • Cochlear implants can adopt greener materials and sustainable practices.

  • Green Teams drive awareness and action in cochlear implant sustainability.

  • Early activation reduced travel lower patient-related emissions.

  • Greener anesthesia and OR recycling cut the surgical environmental impact.

  • The cochlear implant field can lead in aligning healthcare with SDGs.

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Case reports
Endonasal endoscopic treatment of a rare advanced Teratocarcinosarcoma of skull base
Lucas Sousa Salgado, Vinicius Domene, Thomas Peter Maahs, Rafael de Castro da Silva, Vanessa Carvalho de Oliveira, Renata Papatella Araujo, Carlos Takahiro Chone
Braz J Otorhinolaryngol. 2025;91:
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Brazilian Journal of Otorhinolaryngology (English Edition)
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Articles submitted as of May 1, 2022, which are accepted for publication will be subject to a fee (Article Publishing Charge, APC) payment by the author or research funder to cover the costs associated with publication. By submitting the manuscript to this journal, the authors agree to these terms. All manuscripts must be submitted in English.. Os artigos submetidos a partir de 1º de maio de 2022, que forem aceitos para publicação estarão sujeitos a uma taxa (Article Publishing Charge, APC) a ser paga pelo autor para cobrir os custos associados à publicação. Ao submeterem o manuscrito a esta revista, os autores concordam com esses termos. Todos os manuscritos devem ser submetidos em inglês.