Surgical treatment improves survival and recurrence-free outcomes in OSCC.

Early-stage tumors have lower recurrence rates and better prognosis.

Advanced-stage diagnosis significantly worsens outcomes.

Large cohort study with over 10,000 patients from São Paulo, Brazil.

The causal relationship between enzymes and tinnitus remain unclear.

5 proteases have protective effect on tinnitus and 4 proteases promote tinnitus.

Tinnitus reduce the content of 2 proteases and increase the content of 4 proteases.

A foundation for finding effective treatment targets for tinnitus was laid.

CXCR4+ NPC cells show enhanced stemness, EMT, and metastasis.

CXCR4 correlates with NPC T/N stage and promotes tumor sphere formation.

SDF-1/CXCR4 axis drives metastasis with 500% increased lung nodules.

CXCR4+ subset upregulates Snail, Twist, Oct4, and downregulates E-cadherin.

CXCR4 may serve as a biomarker and therapeutic target for NPC.

MDCT was used to evaluate 600 infraorbital canals in 300 patients.

Suspended (Type 3) canal prevalence 13%, linked to Haller cells in 21.2%.

Type 3 canals were larger (D1, D2) and more common in younger patients.

Type 3 IOC raises nerve injury risk in sinus and endoscopic surgeries.

Preoperative MDCT is key to detect variants and improve surgical safety.

Bone conduction thresholds were higher in AS and PsA vs. healthy controls.

Hearing loss may indicate subclinical cochlear involvement in SpA.

No significant difference was found between AS and PsA thresholds.

No consistent link between hearing thresholds and disease activity was seen.

Routine hearing tests may be needed in SpA, even without symptoms.

Olfato-Up is a new Brazilian olfactory test designed for cost reduction and reusability.

The test demonstrated high reproducibility, sensitivity, specificity, and accuracy.

Validation was conducted in the Brazilian adult and elderly population.

Systematic elucidation of LAT-IL23R amino acid metabolic network in CRS.

Construction of “gene-protein-metabolite” regulatory network via MR and mediation.

LAT-IL23R axis modulates CRS via γ-glutamyltyrosine and trans-4-hydroxyproline.

Theoretical basis for targeted therapies against chronic rhinosinusitis.

First pooled analysis of Olopatadine/Mometasone FDC.

Reinforces significant improvements compared to mometasone and olopatadine.

Compiled safety data demonstrate low AEs and high adherence to treatment.

CD40LG expression demonstrates independent prognostic significance in HNSCCs.

A 7-feature CT radiomics model non-invasively predicts CD40LG expression.

RS mapping CD40LG expression serves as an independent prognostic marker for HNSCCs.

This study establishes a link between plasma metabolites and the risk of head and neck cancer.

1,2-dipalmitoyl-gpc (16:0/16:0), P-cresol glucuronide, and Nisinate (24:6n3) can improve the risk of head and neck cancer.

Targeting plasma metabolites can offer strategies for head and neck cancer’s treatment.

Deep learning shows great promise for diagnosing cochlear malformation.

ResNet50 and DenseNet121 demonstrate well compared to the chief physician.

Deep learning may be a valuable aid for experienced radiologists.

First bibliometric analysis of global allergic rhinitis immunotherapy research.

Triple shift: therapy→biologics, diagnostics→molecular, care→integrated.

Anti-IgE (omalizumab) and anti-IL-4Rα (dupilumab) are key biologics.

To assess the impact of HBOT as an initial treatment on ISSNHL prognosis.

HBOT combined with steroids did not significantly improve hearing recovery compared to steroids alone after PSM.

Propensity Score Matching (PSM) was used to balance covariates between groups and reduce confounding factors.

Negligence is the more frequent error committed by ENT in São Paulo State.

Most of the ethical penalties applied to ENT for medical error, were confidential.

Rhinology and Pharyngology were the areas with the highest number of convictions.

Otology was the subspecialty with the highest number of complaints.

Identified high serum uric acid as a risk factor for chronic sinusitis.

Association observed in individuals with higher education and urban residents.

No significant link found between lipid or glucose metabolism and sinusitis risk.

Study underscores potential role of metabolic dysregulation in CRS pathogenesis.

Elevated mascRNA expression in Laryngeal squamous cell carcinoma clinical samples.

mascRNA enhances the proliferative capacity of LSCC cells and promotes tumor occurrence.

mascRNApromotes migration and invasion in LSCC cells.

COVID-19 sharply reduced hearing diagnostic procedures in March 2020.

Recovery was uneven: North/Northeast rebounded; São Paulo lagged.

Post-pandemic screening decline risks delayed pediatric diagnoses.

OAE and ABR exceeded pre-pandemic levels, audiometry recovery modest.

Regional inequities persisted, reflecting wealth and infrastructure gaps.

NCCN guidelines used as reference for AI-driven cancer care evaluation.

LLMs tested for accuracy in oropharyngeal malignancy management.

Majority of AI outputs aligned with guideline-based recommendations.

Discrepancies highlighted areas where AI support remains limited.

Study reinforces AI as an adjunct, not a replacement, in oncology care.

Meniere's disease is a rare chronic inner ear disorder with a diverse symptomatology.

Characteristics of audiovestibular symptoms is crucial for determining a diagnosis.

Disease progression increases hearing loss and vestibular hypofunction.

The ascending type of curve is more common in earlier stages and in younger subjects.

Flat type of curve is more common in later stages and in older subjects.

Binaural Interaction Component is an objective method for analyzing binaurality.

The BIC reflects the ability to recognize and integrate different auditory stimuli.

Auditory Evoked Potentials are neuroelectric activities of the auditory pathway.

Colombian study characterizing HPV genotypes in head and neck cancer.

Predominance of HPV-associated oropharyngeal squamous carcinomas.

HPV-16 identified as main genotype with other high-risk variants.

Strong concordance between HPV DNA and p16 expression confirmed.

Supports genotype-based HPV surveillance and prevention in Colombia.

Spreader grafts protect essential voice formants in aesthetic rhinoplasty cases.

Significant acoustic deterioration observed in patients without spreader grafts.

Rhinoplasty may alter F3–F4 formants, affecting singer’s and speaker’s clusters.

Spreader grafts prevented postoperative rise in VHI-10 voice handicap scores.

First prospective double-blind trial evaluating voice outcomes in rhinoplasty.

Neonatal Hearing Screening coverage in Brazil fell to 26.39% in 2023.

South led with 62.52% and the Federal District reached 83.19% coverage in 2023.

Auditory Brainstem Response tests have risen in number and proportion since 2018.

vHIT showed 42% sensitivity and 89% specificity for vestibular migraine.

Abnormal vHIT findings in 43% of patients with vestibular migraine.

Covert or overt saccades were reported in 36% of the included cases.

High specificity suggests vHIT may help rule in vestibular migraine.

Sialendoscopy treats successfully facial cosmetic surgery salivary duct injury.

There is 100% salivary gland function preservation using sialendoscopy.

Facial cosmetic Surgery complications are rare, likely underreported globally.

Our study adds 5 new cases of sialendoscopy; 27 cases in total reported to date.

We strongly recommend early sialendoscopy for these cosmetic complications.

Classification based on the analogy of sedimentation and tides.

Siltation effect refers to conditions that block blood in the vertebrobasilar system.

Tidal effect includes disorders that globally impair perfusion.

Recognizing these mechanisms guide therapeutic decision-making.