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Journal Information
Issue
Cover Vol. 92. Issue 5. (In progress) Vol. 92. Issue 5. (In progress)
(September - October 2026)
This issue is in progress but contains articles that are final and fully citable.
Editorials
Superior laryngeal nerve block
Gustavo Polacow Korn, C. Blake Simpson
Braz J Otorhinolaryngol. 2026;92:
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Original articles
Translation, cross-cultural adaptation, and validation into Brazilian Portuguese of the Functional Rhinoplasty Outcome Inventory-17 (FROI-17) for use in patients undergoing Functional Rhinoplasty
Maria Eduarda Malosá Jorge, Ana Caroline Soares Silva, Araken Quedas, Daniela Malheiros, Guilherme Mororo, Ingo Baumann, Eduardo Landini Lutaifi Dolci, Cinthya Cosme Gutierrez Duran
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Translation, adaptation, and validation of the FROI-17 for Brazilian Portuguese.

  • Process followed COSMIN and cross-cultural adaptation guidelines ensuring equivalence.

  • Validity supported by moderate to strong correlations with SF-36 and SCHNOS scores.

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Exploring causal associations between autoimmune diseases and hearing loss: a mendelian randomization study
Yutong Huang, Shengli Gao, Renzhong Luo
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • MR analysis uncovers causal links between autoimmune diseases and hearing loss.

  • Ankylosing spondylitis shows significant ties to various hearing loss types.

  • Inflammatory bowel diseases are linked to multiple hearing loss subtypes.

  • Early audiological assessment is needed for patients with autoimmune diseases.

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Chronic rhinosinusitis association with small airway disease: Inflammatory biomarkers and lung function using impulse oscillometry
Mariana Dalbo Contrera Toro, Carla Cristina Souza Gomez, Paloma Lopes Francisco Parazzi, Maria Ângela Gonçalves Oliveira Ribeiro, André Moreno Morcillo, José Dirceu Ribeiro, Eulália Sakano
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Blood eosinophils correlated negatively with FEV1, FEV1/FVC ratio, and FEF25–75%.

  • Impulse oscillometry parameters were compatible with small airway disease in CRS patients.

  • A higher SNOT-22 score was associated with lower FVC, FEV1, and Z5.

  • Total IgE and aeroallergen sensitization showed no correlation with spirometry or impulse oscillometry.

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Cortical auditory response and language development in children with microcephaly by Zika virus
Ana Cláudia Figueiredo Frizzo, Kelly Cristina Lira de Andrade, Isabela Tiezi Rombola, Klinger Vagner Teixeira da Costa, Eduardo Federighi Baisi Chagas, Pedro de Lemos Menezes
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • A virus that recently emerged as the Zika virus.

  • Zika virus cause such as neurological, auditory changes.

  • Can lead to speech and language problems and cognitive deficits.

  • The CAEP enable the study of the auditory pathway’s neurofunction.

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Clinical case-control study of the proprioceptive innervation of the pharynx in patients with obstructive sleep apnea
Guilherme Leal Dantas, Maria Luzete Costa Cavalcante, Erika Ferreira Gomes, Fernanda Leal Dantas Sales Pimentel, Matheus Duarte Pimentel, Conceição da Silva Martins
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Pharyngeal muscles present a complex and diverse histological structure.

  • In OSA there is damage to the pharyngeal muscles, mainly due to inflammation.

  • In OSA there is reduced diversity of complex nerve endings in pharyngeal muscles.

  • Superior Pharynx Constrictor muscle is potentially the most impaired in OSA.

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Dual-mechanism therapy for chronic rhinosinusitis via siRNA targeting of bacterial 16S rRNA and disruption of CFTR-pathogen interactions
Bo Wei, Jiaoyu He, Jiaxin Li, Feng Liu
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • First siRNA design targeting 16S rRNA in CRS pathology.

  • Protein docking shows inhibitory interaction (ΔG = −895.9 kcal/mol).

  • In vitro siRNA reduces 16S rRNA expression by 65% (p < 0.01).

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3D facial data analysis and replaceable mold design for customizing CPAP nasal mask cushions
Ding Yang Hsu
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • 3D facial data analysis improves CPAP nasal mask fit and comfort for OSA patients.

  • Replaceable rapid mold design enables efficient production of customized cushions.

  • Customized cushions reduce facial pressure, strap tension, and air leakage.

  • Patients prefer personalized CPAP cushions for long-term use and adherence.

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Genetic association between renal function and hearing loss: a bidirectional Mendelian randomization study
Jun Wang, Xingxing Chen, Linglin Zhou, Yujie Liu, Sulin Zhang, Haowen Huang
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • UACR was a potential risk factor for hearing loss.

  • Increased UACR levels significantly raising the risk of hearing loss.

  • No causal association was observed between eGFR-crea, eGFR-cys, urate, and hearing loss.

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Role of vitamin D receptor and calcium sensing receptor in parathyroid cancer
Dongxue Zhang, Teng Zhao, Dehui Bi, Jian Huang, Tao Jiang, Pengxiang Zhao, Bojun Wei
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • VDR and CaSR were downregulated in parathyroid cancer.

  • VDR and CaSR participate in parathyroid cancer development.

  • VDR and CaSR may have interaction in parathyroid cancer.

  • LncRNAs associated with VDR may act as diagnostic bimomarkers.

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Trajectory of COVID-related tinnitus over the pandemic timeline
Ricardo R. Figueiredo, Andréia A. de Azevedo, Guilherme de M.R. Figueiredo, Berthold Langguth, Norma de O. Penido
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Study with 233 adults with COVID-19, divided into tinnitus and non-tinnitus groups.

  • Data included symptoms, treatments, THI, VAS, HADS, and audiological findings.

  • Post-COVID tinnitus showed distinct features and temporal variation in the pandemic.

  • Large clinical cohort revealed prevalence and psychological impact of tinnitus.

  • Highlights the importance of monitoring hearing and mental health post-COVID.

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Secretoneurin as a novel predictor of metabolic syndrome in patients with obstructive sleep apnea syndrome
İbrahim Arslan, Yasin Aslan, Muzaffer Arı, Hamit Yaşar Ellidağ, Ömer Tarık Selçuk
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Metabolic syndrome is associated with obstructive sleep apnea syndrome.

  • Secretoneurin may contribute to the development of metabolic syndrome.

  • Secretoneurin level is positively correlated with triglyceride level.

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Effect of Le Fort I osteotomy on the sinonasal region: three-dimensional study
Caio César Gonçalves Silva, Tatiane Fonseca Faro, Marcelo Soares dos Santos, Emanuel Dias de Oliveira e Silva, Jose Rodrigues Laureano Filho
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Discontinuity of the sinus walls, nasal cavity and nasal septum are common.

  • Increased mucosal thickening of the maxillary sinuses in the postoperative period.

  • Volumetric reduction of the maxillary sinus and nasal cavity in the postoperative.

  • Monitoring of factors that may interfere with sinus homeostasis is suggested.

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Endolymphatic hydrops and its association with Magnetic Resonance Imaging and serum vitamin D levels
Tao Lin, Xiaoting Wang, Luguang Zhang, Jing Li, Ling Ding
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Endolymphatic hydrops is most prevalent in Meniere’s disease.

  • VD is directly associated with contralateral SPV and LF-PTA.

  • The affected side SPV and SP/AP values were both related to the degree of VH and CH.

  • VD may be related to early episodic vertigo and fluctuating hearing loss in MD.

  • Early detection of VD levels is crucial for patients with Meniere’s disease with EH.

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Impact of the COVID-19 pandemic on individuals working in otolaryngology: a cross-sectional survey
Charmaine Szalay-Anderson, Benjamin Ewanchuk, Ranjani Somayaji, Derrick R. Randall
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • OHNS and allied health practitioners felt increased risk of coronavirus exposure.

  • Practitioners were mostly concerned about transmitting virus to loved ones.

  • Practitioners mostly agreed with restrictions imposed but not timing or degree.

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Delayed hearing loss in congenital cytomegalovirus infection: systematic review and meta-analysis
Nicolau Moreira Abrahão, Arthur Menino Castilho, Eduardo Tanaka Massuda, Vagner Antonio Rodrigues da Silva
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • The Worldwide rate of congenital cytomegalovirus infection ranges from 0.2% to 2%.

  • About 10% of asymptomatic children will develop hearing impairment over the years.

  • All those children won’t be identified because there isn’t a neonatal screening.

  • Newborn screening enables auditory monitoring through Auditory Brainstem Response.

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Quality-of-life outcomes before and after multilevel pharyngeal surgery in moderate-to-severe obstructive sleep apnea
Na Hua, Yujing Fan, Yanzhe Lyu, Guili Deng, Jizhe Wang, Xiuli Liu
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Quality-of-life gains after multilevel surgery in moderate-to-severe OSA.

  • DHI, THI, PSQI and ESS all dropped significantly postoperatively.

  • AHI and LSaO2 were the main factors influencing postoperative quality of life.

  • Higher baseline AHI plus lower LSaO2 yielded better outcomes.

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Hsa-mir-1293/GLI1/PTCH1 axis is involved in proliferation, migration, and EMT of laryngeal cancer
Yibo Zhou, Yu Ren, Zhi Chen, Jun Wan, Yongchuan She, Yi Tang, Dan Yang, Hong Guo, Zhongxi Huang
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • The hsa-mir-1293/GLI1/PTCH1 axis is a novel pathway in laryngeal cancer.

  • Hsa-mir-1293 is down-regulated and directly targets GLI1.

  • Hsa-mir-1293 suppresses tumor cell proliferation and migration.

  • GLI1 promotes cancer via transcriptional activation of PTCH1.

  • PTCH1 enhances tumor invasion and epithelial-mesenchymal transition.

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Effect of speaking valves on early mobilization of patients in intensive care units following tracheostomy: a prospective randomized controlled trial
Yujun Chen, Yi Lou, Jiabin Cheng, Na Zhao, Saize Huang, YaJie Zhu, Qinhong Xu
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • The use of speaking valves in ICU patient’s post-tracheotomy improved respiratory.

  • Patients using SVs showed higher EQ-5D-5L scores.

  • The findings emphasize the potential of SVs to enhance early mobilization.

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Position paper of Brazilian Society of Head and Neck Surgery among competencies in Head and Neck Surgery teaching for general Surgery residents
Mario Augusto Ferrari de Castro, Rogério Aparecido Dedivitis, Fátima Cristina Mendes de Matos, Marianne Yumi Nakai, Leandro Luongo de Matos, Marco Aurélio Vamondes Kulcsar, Carlos Takahiro Chone, Luiz Paulo Kowalski, ... Thiago Yuuki Kuroiwa
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • A consensus defined head and neck surgery competencies for general surgery residents.

  • A Delphi methodology was used to achieve agreement on essential competencies.

  • The competency framework standardized surgical education.

  • This study contributes to curriculum development in general surgery programs.

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Head-to-head comparison of 18F-PSMA and 18F-FDG PET/CT in locoregionally advanced head and neck squamous cell carcinoma: a pilot study
Hádila da Silva Veras Sousa, Victor Cabral Costa Ribeiro Heringer, Matheus Yung Perin, Nájua Abou Arabi Silveira, Simone Kuba, Ligia Traldi Macedo, Gustavo Jacob Lourenço, Carlos Takahiro Chone, ... Carmen Silvia Passos Lima
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • 18F-FDG, a marker of glycolytic activity, has been used for HNSCC staging.

  • The role of 18F-PSMA-1007, a marker of angiogenesis, in HNSCC is unknown.

  • This study compared 18F-FDG and 18F-PSMA-1007 PET/CT in 14 patients with HNSCC.

  • Tumors were better detected by 18F-FDG PET/CT than by 18F-PSMA-1007 PET/CT.

  • Both tracer uptakes show glycolysis and neoangiogenesis coexist in HNSCC.

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Immune response and stuttering: the potential link between cytokines and stutter
Saime Güzelsoy Sagiroglu, Metin Kılınc, Israfil Orhan, Omer Faruk Cinar, Muhammed Gazi Yıldız, Adem Doganer, Emine Elif Altuntas
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • This study is the first to propose a neuroinflammation hypothesis for stuttering.

  • Serum IL-1, IL-8, and TNF-α levels were significantly higher in stuttering children.

  • The immune system may have a potential role in the pathophysiology of stuttering.

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Review articles
Brazilian Society of Otology Task Force – bone-anchored hearing system – recommendations based on strength of evidence
Rogério Hamerschmidt, Felippe Felix, Robinson Koji Tsuji, Mariana Moreira de Castro Denaro, Pauliana Lamounier, Arthur Menino Castilho, Vagner Antonio Rodrigues Silva
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Selection of implantable hearing technology should be based on shared decision-making with the patient/family, including discussion of benefits, limitations (including MRI), risks, self-care, and aesthetic preferences.

  • Simultaneous ear reconstruction and BAHS implantation may be considered when technically feasible and safe. Staged approaches are also acceptable and may be preferred in cases of complex anatomy.

  • BAHS should not be indicated as a primary treatment for tinnitus in patients with SSD and profound unilateral hearing loss.

  • In otosclerosis, stapedotomy should remain the standard strategy when indicated and performed by an experienced surgeon. BAHSs/active implants should be reserved for exceptional situations (unfavorable anatomy, only-hearing ear, occupational risk).

  • Passive and active transcutaneous systems should be considered preferred alternatives to percutaneous devices when the primary goal includes reducing skin complications and the need for revision surgery, accepting potential small audiometric differences.

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Urgent and emergency tracheostomy in head and neck cancer: practical guide from the Brazilian Society of Surgical Oncology (SBCO)
Carlos Eduardo Santa Ritta Barreira, Terence Pires de Farias, Fernando Luiz Dias, Roberto Rego Monteiro de Araujo Lima, Izabella Costa Santos, Stenio Roberto de Castro Lima Santos, Heládio Feitosa, Rodrigo Nascimento Pinheiro, ... Luiz Paulo Kowalski
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Consensus-based guidance for urgent/emergency tracheostomy in head and neck cancer.

  • Clinical, endoscopic, and contextual criteria guide airway decision-making.

  • Early airway “window of opportunity” recognition prevents catastrophic obstruction.

  • Awake tracheostomy under local anesthesia is preferred in high-risk patients.

  • Tracheostomy planning should preserve the subsequent oncologic treatment strategy.

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Intrathyroid parathyroid carcinoma and its diagnostic challenges ‒ case report and systematic review
Beatriz Ferreira Maraccini, Barbara Guidolin Froner, Fernando Canola Alliegro, Pablo Soares Gomes Pereira, Leandro Luiz Lopes de Freitas, Camila Matsunaga de Angellis, Ana Maria da Cunha Mercante
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Extremely rare presentation of intrathyroidal parathyroid carcinoma.

  • Diagnosis often mistaken for primary thyroid neoplasm.

  • Most cases show hypercalcemia, few are normocalcemic.

  • En bloc resection ensures best long-term disease control.

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Association of chronic kidney disease and risk of hearing loss: a systematic review and meta-analysis
Yang Li, Yuanyuan Zhu, Mian Zhang, Ni Li, Delan Zeng, Jingxuan Wei
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • This study addresses gaps in previous meta-analyses, showing CKD increases HL risk.

  • CKD patients in Asia, especially China, have a higher risk of developing HL.

  • Male CKD patients were more likely to develop HL than females.

  • CKD patients aged between 45 and 64 have a higher risk of developing HL.

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Beyond steroid monotherapy: a systematic review and meta-analysis of combination therapy for severe to profound sudden sensorineural hearing loss
Carolina Tobar Palacios, Laura Valentina Pulido González, Linda Vanessa Gómez Triana, María Victoria Barrios Olaya, Paula Daniela Sánchez Peña, Juan Pablo Alzate Granados
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Combination therapy enhances hearing recovery in severe-profound SSNHL.

  • Improves pure-tone average gain and speech discrimination ability.

  • Early treatment initiation leads to superior auditory outcomes.

  • Evidence limited by study heterogeneity and moderate risk of bias.

  • Large, randomized trials are required to confirm clinical benefit.

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Case reports
Occipital abscess associated with cholesteatoma: a case illustrating possible infectious spread
Kanu Lal Saha, Bishwajit Bhowmik
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • First reported occipital subperiosteal abscess secondary to pediatric cholesteatoma.

  • Infection spread via thrombosed sigmoid sinus and patent mastoid emissary vein.

  • CT and contrast MRI delineated sinus thrombosis, tract, and occipital abscesses.

  • Modified radical mastoidectomy with abscess drainage achieved durable cure.

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Management of cerebrospinal fluid leak after anterior clinoidectomy through an endoscopic endonasal approach: report of two cases
Rosario María Pérez Contreras, Melisa Rocío Gerloff, Enrique Herrera, Oscar Alejandro Paoletti
Braz J Otorhinolaryngol. 2026;92:
Highlights

  • Endoscopic endonasal repair successfully managed CSF leaks after clinoidectomy.

  • Multilayer reconstruction achieved durable, recurrence-free closure.

  • Gasket-seal and nasoseptal flap techniques provided watertight repair.

  • Technique selection should be individualized according to defect features.

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Laryngoscopic findings secondary to Influenza A infection: Report of two cases
Gustavo Polacow Korn, Renata Rangel Azevedo, Octavio Sakahara Saito, Isadora Serotini Pertinhez
Braz J Otorhinolaryngol. 2026;92:
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Letters to the editor
Brazilian Journal of Otorhinolaryngology (English Edition)