Journal Information
Vol. 88. Issue S4.
Pages S1-S230 (November - December 2022)
Original articles
The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx
Akın Şahin, Necati Enver, Selim Yiğit Erçetin, Zeliha Leyla Cinel, Abdullah Çağlar Batman
Braz J Otorhinolaryngol. 2022;88 Supl 4:S1-S8

  • Gelsolin overexpression significantly correlated with unfavorable survival.

  • Increased gelsolin expression was associated with lymphovascular invasion.

  • Gelsolin expression was higher in patients with advanced-stage laryngeal carcinoma.

  • Locoregional recurrence risk is higher in cases wıth gelsoline overexpression.

  • Gelsolin expression could be regarded as a novel independent prognostic biomarker.

Open access
Extracranial non-vestibular head and neck schwannomas: a case series with the review of literature
Deviprasad Dosemane, Sushmitha Kabekkodu, Bhagyashree Jaipuria, Suja Sreedharan, Vijendra Shenoy
Braz J Otorhinolaryngol. 2022;88 Supl 4:S9-S17

  • Head and neck schwannomas commonly present as a painless swelling in the neck, mostly in middle-aged females.

  • Contrast computed tomography and magnetic resonance images can guide the diagnosis as well as surgery.

  • Fine needle aspiration cytology with cellular smears is a cost-effective diagnostic tool for superficial lesions.

  • Complete enucleation with preservation of nerve of origin is the preferred treatment modality, with negligible recurrence.

  • Postoperative nerve palsy may be seen if the nerve of origin is not adequately identified or inaccessible.

Open access
Prognostic importance of expression of mini-chromosome maintenance proteins (MCMs) in patients with nasopharyngeal cancer treated with curative radiotherapy
Gul Kanyilmaz, Pembe Oltulu, Berrin Benli Yavuz, Meryem Aktan
Braz J Otorhinolaryngol. 2022;88 Supl 4:S18-S25

  • In nasopharyngeal cancers, the most important therapeutic problem in treatment resistance is radiation resistance.

  • Minichromosome maintenance complex has a critical function in DNA replication and oncogenic signaling pathways.

  • In the current study, the overexpression of minichromosome maintenance complex 2, 3, 5, 6 and 7 indicated bad prognosis.

  • Minichromosome maintenance complex 7 was an independent prognostic factor for survival outcomes and may be a potential therapeutic target for the treatment of nasopharyngeal cancer.

Open access
Validation of a classification and scoring system for the diagnosis of laryngeal and pharyngeal squamous cell carcinomas by confocal laser endomicroscopy
Matti Sievert, Konstantinos Mantsopoulos, Sarina K. Mueller, Robin Rupp, Markus Eckstein, Florian Stelzle, Nicolai Oetter, Andreas Maier, ... Miguel Goncalves
Braz J Otorhinolaryngol. 2022;88 Supl 4:S26-S32

  • Confocal laser endomicroscopy enables real-time, non-invasive identification of malignancy in pharynx and larynx.

  • Confocal laser endomicroscopy classification scores for the oral mucosa are also valid in pharynx and larynx.

  • Sensitivity and specificity for carcinoma was 81.3% and 85.5%, respectively.

  • Confocal laser endomicroscopy can be performed with substantial interrater agreement (k = 0.64).

  • Presently confocal laser endomicroscopy can aid intraoperative assessment but does not replace histology.

Open access
Long-term functional outcomes and quality of life after partial glossectomy for T2 squamous cell carcinomas
Giuseppe Riva, Silvia Sapino, Mattia Ravera, Giulia Elia, Giancarlo Pecorari
Braz J Otorhinolaryngol. 2022;88 Supl 4:S33-S43

  • Partial glossectomy and reconstruction strategy influences speech and swallowing.

  • Patients with a higher tongue motility had better articulation and less dysphagia.

  • Worse functional outcomes induced a lower quality of life.

Open access
Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory?
Ory Madgar, Nir Livneh, Alex Dobriyan, Elad Dagan, Eran E. Alon
Braz J Otorhinolaryngol. 2022;88 Supl 4:S44-S49

  • Airway management following maxillofacial microvascular reconstruction is complex.

  • Lack of consensus exists regarding the optimal airway management perioperatively.

  • Routine use of tracheostomy is unnecessary.

  • Tracheostomy should be considered on a case-to-case basis.

Open access
Cone beam computed tomography with oral contrast for accurate diagnosis and surgical planning of pharyngeal leakage and fistula: a case series
Mitsuyoshi Imaizumi, Toshihiko Suzuki, Shigeyuki Murono
Braz J Otorhinolaryngol. 2022;88 Supl 4:S50-S57

  • We evaluated pharyngeal leakage and fistulae using contrast CBCT.

  • Contrast CBCT provides three-dimensional images taken in a sitting position.

  • Contrast CBCT is useful for accurate diagnosis of leakage and fistula.

  • Contrast CBCT may be an effective option to detect pharyngeal leakage and fistulae.

Open access
The added value of non-contrast 3-Tesla MRI for the pre-operative localization of hyperparathyroidism
Yoshitaka Kawai, Mami Iima, Hirotaka Yamamoto, Makiko Kawai, Ayami Ohno Kishimoto, Sho Koyasu, Akira Yamamoto, Koichi Omori, Yo Kishimoto
Braz J Otorhinolaryngol. 2022;88 Supl 4:S58-S64

  • Sensitivity raised by unenhanced 3-Tesla MRI with US and MIBI in hyperparathyroidism.

  • MRI could detect every parathyroid lesion that had been found in US.

  • Undetected lesions in MRI were 6 mm or less, which are size of normal parathyroid.

  • Fat-suppressed T2-weighted images could exhibit parathyroid lesions conspicuously.

Open access
Secondary tracheoesophageal puncture with a flexible transillumination device: a new technique and its outcomes
Amanda Sampaio Almeida, Flavio Mignone Gripp, Fabio Lau, Eduardo Vieira Couto, Carlos Takahiro Chone
Braz J Otorhinolaryngol. 2022;88 Supl 4:S65-S69

  • Secondary TEP under local anesthesia generates fewer costs.

  • Using flexible transillumination device reduces the risk of complications.

  • Success rates of VP encourage its adoption in laryngectomee patients.

Open access
Survival analysis of patients with subglottic squamous cell carcinoma based on the SEER database
Fan Yang, Lu He, Yuansheng Rao, Yanjun Feng, Jianhong Wang
Braz J Otorhinolaryngol. 2022;88 Supl 4:S70-S80

  • Prognosis of subglottic squamous cell carcinoma remained poor over the years.

  • Combination of surgery and adjuvant therapies improved the survival outcomes.

  • Early-stage tumors benefited from larynx preservation surgery; advanced tumors benefited from total laryngectomy.

Open access
The role of vein grafts in reconstructive head and neck microsurgery
Chih-Sheng Lai, Yi-Ting Chang, Ching-Hui Shen, Yueh-Chi Tsai, Chen-Te Lu, Jung-Hsing Yen, I-Chen Chen, Yi-Ling Lin
Braz J Otorhinolaryngol. 2022;88 Supl 4:S81-S88

  • Vein grafting is a reliable option for challenging head and neck reconstruction.

  • Vein grafting is a reliable option in free flap salvage cases.

  • High free flap survival rate shows vein graft reliability.

  • An increased postoperative complication in free flap with vein grafting is noted.

Open access
Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer
Lorenzo Fernandes Moça Trevisani, Isabelle Fernandes Kulcsar, Ana Kober Nogueira Leite, Marco Aurélio Vamondes Kulcsar, Graziele Aparecida Simões Lima, Rogerio Aparecido Dedivitis, Luiz Paulo Kowalski, Leandro Luongo Matos
Braz J Otorhinolaryngol. 2022;88 Supl 4:S89-S97

  • Patients with oral SCC present significant weight loss and immune compromise.

  • Increased values of RDW and high weight loss were risk factors for lower survival.

  • Patients undergoing treatment must receive a complete nutritional evaluation.

  • Nutritional intervention can be effective, preventing nutritional deterioration.

Open access
Impact of radiotherapy for nasopharyngeal carcinoma on carotid stenosis risk: a meta-analysis
Huiqing Liang, Yuanyong Zhou, Wei Xiong, Suimin Zheng
Braz J Otorhinolaryngol. 2022;88 Supl 4:S98-S107

  • Radiotherapy (RT) serves as the most effective treatment for Nasopharyngeal Carcinoma (NPC) and can cause carotid stenosis.

  • This meta-analysis of 16 studies assessed the impact of RT on carotid stenosis in NPC patients, as well as to explore the risk factors for significant carotid stenosis.

  • Results showed that RT increased the risk of carotid stenosis in patients with NPC. Age, smoking habit and time interval from radiotherapy were independent predictors of significant carotid stenosis.

Open access
MicroRNA-375 inhibits laryngeal squamous cell carcinoma progression via targeting CST1
Feng Dai, Zuojun Xie, Qiming Yang, Zhuanglong Zhong, Chun Zhong, Yongliang Qiu
Braz J Otorhinolaryngol. 2022;88 Supl 4:S108-S116

  • miR-375 is lowly expressed in LSCC cell lines.

  • miR-375 regulates the proliferation, migration and invasion of LSCC cells.

  • miR-375 targets CST1.

  • miR-375 inhibits proliferation of LSCC cells by targeting CST1.

Open access
Free three-dimensional image software in local extension assessment of oral squamous cell carcinoma: a pilot study
João Pedro Perez Gomes, André Luiz Ferreira Costa, Carlos Takahiro Chone, Albina Messias de Almeida Milani Altemani, João Maurício Carrasco Altemani, Carmen Silvia Passos Lima
Braz J Otorhinolaryngol. 2022;88 Supl 4:S117-S123
Open access
Prognostic factors in oropharyngeal squamous cell carcinoma in the state of São Paulo, Brazil: 10-year follow-up
Fabio Lau, Jonas Belchior Tamanini, Fabio Portella Gazmenga, Gustavo Mercuri, Vanessa Carvalho de Oliveira, Daniel Naves Araújo Teixeira, Eduardo Vieira Couto, Carlos Takahiro Chone
Braz J Otorhinolaryngol. 2022;88 Supl 4:S124-S132

  • Among patients with oropharyngeal squamous cell carcinoma, 86.3% had advanced-stage disease and 13.7% had early-stage disease at diagnosis.

  • Disease-free survival did not differ significantly between patients receiving medical and surgical treatment among patients with the same staging.

  • Patients receiving medical treatment had shorter overall survival in both early and advanced stages of the disease compared with those undergoing surgery.

Open access
CD45RO+TILs: cellular biomarkers for larynx squamous cell carcinoma outcome
Yousef Mohammadi, Simin Ahmadvand, Maryam Mirtalebi, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi
Braz J Otorhinolaryngol. 2022;88 Supl 4:S133-S142

  • TILs may control tumor or delay the acquiring of aggressive phenotypes.

  • Higher number of TILs in primary tumor tissues are associated with favorable prognosis.

  • Higher number of CD45RO+TILs may be an indicator of efficient anti-tumor immune responses.

  • CD45RO+ cells are a valuable biomarker for predicting prognosis of larynx SCC patients.

Open access
Correlation between PET-CT and ct in the staging after the treatment of head and neck squamous cell carcinoma
Fernando García-Curdi, Yolanda Lois-Ortega, Ana Muniesa-del Campo, Amaranta McGee-Laso, José Miguel Sebastián-Cortés, Héctor Vallés-Varela, Julio José Lambea-Sorrosal
Braz J Otorhinolaryngol. 2022;88 Supl 4:S143-S151

  • Head and neck cancer recurs more frequently in the first 2–3 years after treatment.

  • Early detection of recurrence events is important.

  • Diagnostic imaging methods are an indispensable tool in the follow up of the disease.

  • The post-treatment neck study is controversial.

Open access
Parotidectomy and neck dissection in locally advanced and relapsed cutaneous squamous cell carcinoma of the head and neck region
Giulianno Molina de Melo, Luiz Henrique Guilherme, Marcel das Neves Palumbo, Marcello Rosano, Murilo Catafesta das Neves, Fabiano Mesquita Callegari, Marcio Abrahao, Onivaldo Cervantes
Braz J Otorhinolaryngol. 2022;88 Supl 4:S152-S162

  • Parotidectomy and neck dissection in locally advanced (laCSCC) and relapsed Cutaneous Squamous Cell Carcinoma (reCSCC) were evaluated.

  • Worst survivals were observed in T4, positive P stage and positive parotid metastasis.

  • The parotid metastasis was present in 50% with OR = 37.6 to evolve into positive neck metastasis.

  • The occult, neck metastasis and neck extracapsular spread rate was 13.5%, 51.3% and 37.8%.

  • We propose partial for P0 or total parotidectomy for P1-3 and neck dissection to all these patients.

Open access
Feasibility of a snowball sampling survey to study active surveillance for thyroid microcarcinoma treatment among endocrinologists and surgeons of Brazil
Isabela Matos da Silva, Taísa Quécia da Silva Nogueira, Deborah Nogueira Couto, Paula Cristina Tanajura Meira Lima, Natália Sampaio Carvalho Bonfim, Izadora Gomes Veiga de Sousa, Ana Clara Tosta Telles, Fábio Hecht, ... Helton Estrela Ramos
Braz J Otorhinolaryngol. 2022;88 Supl 4:S163-S169

  • Active surveillance for low risk papillary microcarcinoma is a strategy to prevent excessive early treatment, among other advantages.

  • Snowball sampling strategy is feasible and able in reaching hard-to-reach groups, such as doctors of different specialties, in different work environments or in large countries.

  • In Brazil, total thyroidectomy seems to be the most indicated treatment for thyroid papillary microcarcinoma.

Open access
Computed tomography analysis of fascial space involvement demonstrates correlations with laboratory tests, length of hospital stays and admission to the intensive care unit in odontogenic infections
Renata de Jesus da Silva, Raphaella Ayres Lima Barbosa, Fabio Kenji Okamura, João Gualberto Cerqueira Luz
Braz J Otorhinolaryngol. 2022;88 Supl 4:S170-S176

  • The involvement of primary spaces predominated in disseminated odontogenic infections.

  • Laboratory tests higher values are related to greater involvement of fascial spaces.

  • Greater hospitalization stays are related to greater involvement of fascial spaces.

  • Intensive care unit admission is related to greater involvement of fascial spaces.

Open access
Review articles
Osteolipoma of head and neck – a review
Billy L.K. Wong, Christopher Hogan
Braz J Otorhinolaryngol. 2022;88 Supl 4:S177-S187

  • 80% of the patients with osteolipoma presented with a painless mass which had pre-existed for at least 4-months contrary to a lump associated with a malignant process.

  • Histology consisting of variable mixture of adipose tissue interspersed with lamellar bone, woven bone, cancellous bone, compact bone and osteoblasts is key to confirm the diagnosis of osteolipoma.

  • Osteolipoma should not be confused with other benign tumours with bony element including parosteal lipomas and intraosseous lipomas.

  • Recognising osteolipoma early is important for patient reassurance as well as avoiding unnecessary radical treatment.

Open access
Case reports
First renal metastasis report from tongue cancer
Mustafa Korkmaz, Melek Karakurt Eryılmaz, Mustafa Karaağaç, Mehmet Artaç
Braz J Otorhinolaryngol. 2022;88 Supl 4:S188-S191
Open access
Primary intraoral epithelioid hemangioendothelioma of the tongue: a case report and review of literature
Ekanayake Mudiyanselage Kanchana Medhavi Kumari Weerakoon, Kapu Gamage Kanchana Dewinda Kapugama, Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena
Braz J Otorhinolaryngol. 2022;88 Supl 4:S192-S195
Open access
Tracheal glomus tumor misdiagnosed as pulmonary disease: a case report and literature review
Miao Gao, Sheng-Nan Ye, Chang Lin, Yuan-Teng Xu
Braz J Otorhinolaryngol. 2022;88 Supl 4:S196-S204
Open access
Primary oral leiomyosarcoma of the maxillary bone and sinus: case report and up-to-date review of literature
Niccolò Lombardi, Elena M. Varoni, Dimitri Rabbiosi, Marco Cucurullo, Laura Moneghini, Giovanni Lodi
Braz J Otorhinolaryngol. 2022;88 Supl 4:S205-S211
Open access
Palatine tonsil metastatic colon adenocarcinoma. Case report
Gabriela Morales Medina, Carmen Vallés Rodríguez, Isidora Rettig Infante, Manuela Bayona Romero, Elda Oyarzún Bahamonde, Ángela Enterría González
Braz J Otorhinolaryngol. 2022;88 Supl 4:S212-S214
Open access
Pleomorphic adenoma of the parotid gland presenting as extensively ossified lesion with bone infiltration: a case report
Marcel Mayer, Ruben Thoelken, Monika Jering, Bruno Märkl, Abbas Agaimy, Johannes Zenk
Braz J Otorhinolaryngol. 2022;88 Supl 4:S215-S218
Open access
Kimura's disease with bilateral parotid involvement: a common presentation with an uncommon diagnosis
Hui Yan Ong, Mimi Ezreena Esa, Jia Ji Ng, Shahawiah Abdul Wahab, Santhi Kalimuthu
Braz J Otorhinolaryngol. 2022;88 Supl 4:S219-S222
Open access
A rare foreign body migration: from head to neck
Vedat Delibas, Muhammet Rasit Muharremoglu, Kemal Koray Bal, Sedat Alagoz
Braz J Otorhinolaryngol. 2022;88 Supl 4:S223-S225
Open access
Secondary Ewing’s sarcoma of the temporo-occipital region developed 12-years after medulloblastoma treatment
Zoran Dudvarski, Nenad Arsovic, Jelena Sopta, Emilija Gacic-Manojlovic, Nemanja Radivojevic, Sasa Jakovljevic
Braz J Otorhinolaryngol. 2022;88 Supl 4:S226-S229
Open access
Brazilian Journal of Otorhinolaryngology (English Edition)
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